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Cyclosporin Structure and Permeability: From A to Z and Beyond

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13131-13151

2021

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Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8272-8286

2021

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From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7145-7159

2014

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The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.683-691

2016

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Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding

Biochimica et biophysica acta, 2013-02, Vol.1831 (2), p.398-406

2013

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Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4'-OH)MeLeu] 4 -CsA overproduction

Microbial cell factories, 2017-07, Vol.16 (1), p.120-120, Article 120

2017

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V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

Biochemical journal, 2013-04, Vol.451 (2), p.245-255

2013

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ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport

Toxicological sciences, 2011-06, Vol.121 (2), p.343-356

2011

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Amperometric biosensor based on multilayer containing carbon nanotube, plasma-polymerized film, electron transfer mediator phenothiazine, and glucose dehydrogenase

Bioelectrochemistry (Amsterdam, Netherlands), 2012-04, Vol.84, p.1-5

2012

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Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels

Journal of the American Society of Nephrology, 2015-07, Vol.26 (7), p.1576-1587

2015

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Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

The Journal of pharmacology and experimental therapeutics, 2009-08, Vol.330 (2), p.423-429

2009

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Immunosuppressors and reversion of multidrug-resistance

Critical reviews in oncology/hematology, 2005-10, Vol.56 (1), p.61-70

2005

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Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist MK 801

Mitochondrion, 2013-09, Vol.13 (5), p.539-547

2013

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Liquid chromatography-tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients

Journal of separation science, 2010-08, Vol.33 (15), p.2287-2293

2010

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The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

Journal of biomolecular screening, 2013-04, Vol.18 (4), p.430-440

2013

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Cyclophilin inhibitors for the treatment of HCV infection

Current opinion in investigational drugs (London, England : 2000), 2010-08, Vol.11 (8), p.911

2010

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Cell, 1991-08, Vol.66 (4), p.807-815

1991

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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

Biochemistry (Easton), 1992-04, Vol.31 (16), p.3896-3901

1992

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A fluorescence polarization-based assay for peptidyl prolyl cis/ trans isomerase cyclophilin A

Analytical biochemistry, 2006-09, Vol.356 (1), p.100-107

2006

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Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

The Journal of biological chemistry, 1999-08, Vol.274 (32), p.22581-22585

1999

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Science (American Association for the Advancement of Science), 1991-01, Vol.251 (4991), p.283-287

Schreiber, Stuart L.

1991

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The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.802

1998

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Exo-Mechanism Proximity-Accelerated Alkylations: Investigations of Linkers, Electrophiles and Surface Mutations in Engineered Cyclophilin-Cyclosporin Systems

Chembiochem : a European journal of chemical biology, 2005-05, Vol.6 (5), p.890-899

2005

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Nature (London), 1989-10, Vol.341 (6244), p.758-760

1989

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Immunophilin-sensitive protein phosphatase action in cell signaling pathways

Cell, 1992-08, Vol.70 (3), p.365-368

Schreiber, Stuart L.

1992

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Cyclosporin Structure and Permeability: From A to Z and Beyond

Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives

From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds

The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices

Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding

Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4'-OH)MeLeu] 4 -CsA overproduction

V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins

ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport

Amperometric biosensor based on multilayer containing carbon nanotube, plasma-polymerized film, electron transfer mediator phenothiazine, and glucose dehydrogenase

Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells

Immunosuppressors and reversion of multidrug-resistance

Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist MK 801

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients

The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier

Cyclophilin inhibitors for the treatment of HCV infection

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

A fluorescence polarization-based assay for peptidyl prolyl cis/ trans isomerase cyclophilin A

Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite

Exo-Mechanism Proximity-Accelerated Alkylations: Investigations of Linkers, Electrophiles and Surface Mutations in Engineered Cyclophilin-Cyclosporin Systems

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

Immunophilin-sensitive protein phosphatase action in cell signaling pathways

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