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2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells

The Journal of pharmacology and experimental therapeutics, 2015-11, Vol.355 (2), p.308-328

2015

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In situ click chemistry generation of cyclooxygenase-2 inhibitors

Nature communications, 2017-02, Vol.8 (1), p.1-14, Article 1

2017

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Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Biochemical pharmacology, 2020-10, Vol.180, p.114147-114147, Article 114147

2020

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Activation of Melanocortin 4 Receptors Reduces the Inflammatory Response and Prevents Apoptosis Induced by Lipopolysaccharide and Interferon-γ in Astrocytes

Endocrinology (Philadelphia), 2007-10, Vol.148 (10), p.4918-4926

2007

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Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

European journal of medicinal chemistry, 2021-12, Vol.225, p.113804-113804, Article 113804

2021

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Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities

Food chemistry, 2017-03, Vol.218, p.15-21

2017

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Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors

Bioorganic chemistry, 2019-02, Vol.82, p.86-99

2019

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Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4277-4299

2013

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Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects

European journal of clinical pharmacology, 2014-10, Vol.70 (10), p.1159-1172

Wehling, Martin

2014

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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

European journal of medicinal chemistry, 2016-10, Vol.121, p.410-421

2016

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Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

Angewandte Chemie International Edition, 2020-12, Vol.59 (51), p.23313-23321

International ed. in English, 2020

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Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

Bioorganic & medicinal chemistry, 2020-04, Vol.28 (7), p.115403-115403, Article 115403

2020

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Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

European journal of medicinal chemistry, 2016-11, Vol.123, p.803-813

2016

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Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

Journal of natural products (Washington, D.C.), 2017-04, Vol.80 (4), p.999-1006

2017

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New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

European journal of medicinal chemistry, 2019-12, Vol.183, p.111693, Article 111693

2019

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Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15069-15081

2016

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Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

Nature (London), 2015-01, Vol.517 (7533), p.209-213

2015

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Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach

European journal of pharmacology, 2021-07, Vol.902, p.174091, Article 174091

2021

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Anti-Inflammatory Drugs as Anticancer Agents

International journal of molecular sciences, 2020-04, Vol.21 (7), p.2605

2020

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Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

European journal of medicinal chemistry, 2017-02, Vol.127, p.972-985

2017

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Biochemical journal, 2010-07, Vol.429 (2), p.273-282

2010

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Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Phytomedicine (Stuttgart), 2020-10, Vol.77, p.153284-153284, Article 153284

2020

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Inhibition of cyclooxygenase by blocking the reducing cosubstrate at the peroxidase site: Discovery of galangin as a novel cyclooxygenase inhibitor

European journal of pharmacology, 2021-05, Vol.899, p.174036, Article 174036

2021

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Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

European journal of medicinal chemistry, 2016-08, Vol.118, p.250-258

2016

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Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

European journal of medicinal chemistry, 2021-01, Vol.209, p.112918-112918, Article 112918

2021

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2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Activation of Melanocortin 4 Receptors Reduces the Inflammatory Response and Prevents Apoptosis Induced by Lipopolysaccharide and Interferon-γ in Astrocytes

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors

Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

Mechanistic evaluation of a novel cyclohexenone derivative’s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach

Anti-Inflammatory Drugs as Anticancer Agents

Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Inhibition of cyclooxygenase by blocking the reducing cosubstrate at the peroxidase site: Discovery of galangin as a novel cyclooxygenase inhibitor

Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

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