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Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

European journal of pharmaceutical sciences, 2018-08, Vol.121, p.356-381

2018

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Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors

Bioorganic chemistry, 2019-02, Vol.82, p.86-99

2019

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Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15069-15081

2016

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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

European journal of medicinal chemistry, 2016-10, Vol.121, p.410-421

2016

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Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

Angewandte Chemie (International ed.), 2020-12, Vol.59 (51), p.23313-23321

International ed. in English, 2020

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Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

European journal of medicinal chemistry, 2016-11, Vol.123, p.803-813

2016

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Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

Bioorganic & medicinal chemistry, 2020-04, Vol.28 (7), p.115403-115403, Article 115403

2020

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Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

European journal of medicinal chemistry, 2021-12, Vol.225, p.113804-113804, Article 113804

2021

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Biochemical journal, 2010-07, Vol.429 (2), p.273-282

2010

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Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis

Journal of natural products (Washington, D.C.), 2017-04, Vol.80 (4), p.999-1006

2017

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[3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H‑Azirines and Aldehydes

Organic letters, 2015-08, Vol.17 (16), p.4070-4073

2015

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Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4277-4299

2013

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Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS

Phytomedicine (Stuttgart), 2020-10, Vol.77, p.153284-153284, Article 153284

2020

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New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies

European journal of medicinal chemistry, 2019-12, Vol.183, p.111693, Article 111693

2019

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Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (1), p.28-33

2010

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Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

European journal of medicinal chemistry, 2016-08, Vol.118, p.250-258

2016

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Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors

Molecular diversity, 2020-08, Vol.24 (3), p.673-689

2020

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Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (11), p.127173, Article 127173

2020

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Synthesis, Anti-Inflammatory Activity, and in Vitro Antitumor Effect of a Novel Class of Cyclooxygenase Inhibitors: 4-(Aryloyl)phenyl Methyl Sulfones

Journal of medicinal chemistry, 2010-09, Vol.53 (18), p.6560-6571

2010

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Coumarins scaffolds as COX inhibitors

Bioorganic chemistry, 2017-04, Vol.71, p.146-159

2017

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Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3653-3660

2017

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Thiazoles and Thiazolidinones as COX/LOX Inhibitors

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.685

2018

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Molecular Mechanisms in the Selectivity of Nonsteroidal Anti-Inflammatory Drugs

Biochemistry (Easton), 2018-02, Vol.57 (7), p.1236-1248

2018

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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (11), p.3416-3424

2011

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Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

Journal of the American Chemical Society, 2011-05, Vol.133 (18), p.7222-7228

2011

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