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In situ click chemistry generation of cyclooxygenase-2 inhibitors

Nature communications, 2017-02, Vol.8 (1), p.1-14, Article 1

2017

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Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs

Gastroenterology (New York, N.Y. 1943), 2018-02, Vol.154 (3), p.500-514

2018

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NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Cell, 2018-02, Vol.172 (5), p.1022-1037.e14

2018

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Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6799-6808

2014

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EP1–4 subtype, COX and PPARγ receptor expression in colorectal cancer in prediction of disease‐specific mortality

International journal of cancer, 2007-07, Vol.121 (2), p.232-240

2007

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Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

Biochimica et biophysica acta, 2015-04, Vol.1851 (4), p.422-432

2015

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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

European journal of medicinal chemistry, 2016-10, Vol.121, p.410-421

2016

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The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

Inflammopharmacology, 2013-06, Vol.21 (3), p.201-232

2013

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Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (11), p.127173, Article 127173

2020

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Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways

Scientific reports, 2020-10, Vol.10 (1), p.16204-16204, Article 16204

2020

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Biochemical journal, 2010-07, Vol.429 (2), p.273-282

2010

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Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

Cell, 2016-10, Vol.167 (2), p.471-483.e10

2016

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Digested total protein and protein fractions from chia seed (Salvia hispanica L.) had high scavenging capacity and inhibited 5-LOX, COX-1-2, and iNOS enzymes

Food chemistry, 2019-08, Vol.289, p.204-214

2019

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Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites

Scientific reports, 2020-09, Vol.10 (1), p.15965, Article 15965

2020

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Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

European journal of medicinal chemistry, 2016-11, Vol.123, p.803-813

2016

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Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

British journal of pharmacology, 2019-04, Vol.176 (8), p.1038-1050

2019

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Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention

Cancer and metastasis reviews, 2017-06, Vol.36 (2), p.289-303

2017

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Inhibition of cyclooxygenase by blocking the reducing cosubstrate at the peroxidase site: Discovery of galangin as a novel cyclooxygenase inhibitor

European journal of pharmacology, 2021-05, Vol.899, p.174036, Article 174036

2021

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Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)

Environmental science & technology, 2010-03, Vol.44 (6), p.2176-2182

2010

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Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (1), p.28-33

2010

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Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

European journal of medicinal chemistry, 2017-02, Vol.127, p.972-985

2017

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Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase‑2

Biochemistry (Easton), 2023-11, Vol.62 (21), p.3134-3144

2023

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Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2

Bioorganic chemistry, 2022-04, Vol.121, p.105663-105663, Article 105663

2022

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Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products

British journal of pharmacology, 2011-10, Vol.164 (3), p.894-912

2011

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Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

European journal of medicinal chemistry, 2021-01, Vol.209, p.112918-112918, Article 112918

2021

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In situ click chemistry generation of cyclooxygenase-2 inhibitors

Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

EP1–4 subtype, COX and PPARγ receptor expression in colorectal cancer in prediction of disease‐specific mortality

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects

Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways

Pleiotropic mechanisms facilitated by resveratrol and its metabolites

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

Digested total protein and protein fractions from chia seed (Salvia hispanica L.) had high scavenging capacity and inhibited 5-LOX, COX-1-2, and iNOS enzymes

Dual COX and 5-LOX inhibition by clerodane diterpenes from seeds of Polyalthia longifolia (Sonn.) Thwaites

Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention

Inhibition of cyclooxygenase by blocking the reducing cosubstrate at the peroxidase site: Discovery of galangin as a novel cyclooxygenase inhibitor

Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)

Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase‑2

Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2

Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products

Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

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