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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

Nature communications, 2021-06, Vol.12 (1), p.3356-3356, Article 3356

2021

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Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells

Molecular cancer research, 2018-03, Vol.16 (3), p.361-377

2018

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Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

Nature chemical biology, 2021-05, Vol.17 (5), p.567-575

2021

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RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

Nature (London), 2019-05, Vol.569 (7756), p.423-427

2019

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Pulchranin A: First report of isolation from an endophytic fungus and its inhibitory activity on cyclin dependent kinases

Natural product research, 2020-10, Vol.34 (19), p.2715-2722

2020

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Evidence that the human cell cycle is a series of uncoupled, memoryless phases

Molecular systems biology, 2019-03, Vol.15 (3), p.e8604-n/a

2019

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Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Nature communications, 2024-08, Vol.15 (1), p.6807-14, Article 6807

2024

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Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (37), p.18561-18570

2019

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S‐adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

Hepatology (Baltimore, Md.), 2022-02, Vol.75 (2), p.280-296

2022

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Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (36), p.17990-18000

2019

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Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity

PloS one, 2023-03, Vol.18 (3), p.e0283590-e0283590

2023

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Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (17), p.E1019-E1027

2012

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Type II Inhibitors Targeting CDK2

ACS chemical biology, 2015-09, Vol.10 (9), p.2116-2125

2015

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Fibroblast growth factor 2 induces proliferation and fibrosis via SNAI1-mediated activation of CDK2 and ZEB1 in corneal endothelium

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3758-3769

2018

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Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

PloS one, 2016-11, Vol.11 (11), p.e0166233-e0166233

2016

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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

Nature communications, 2019-04, Vol.10 (1), p.1676-13, Article 1676

2019

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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

PloS one, 2020-07, Vol.15 (7), p.e0234103-e0234103

2020

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An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells

Stem cells (Dayton, Ohio), 2011-04, Vol.29 (4), p.651-659

2011

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Development of CDK2 and CDK5 Dual Degrader TMX‐2172

Angewandte Chemie International Edition, 2020-08, Vol.59 (33), p.13865-13870

International ed. in English, 2020

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KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway

Oncogene, 2015-03, Vol.34 (11), p.1432-1441

2015

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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Nature communications, 2015-04, Vol.6 (1), p.6769-6769, Article 6769

2015

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Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

European journal of medicinal chemistry, 2017-01, Vol.126, p.1118-1128

2017

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Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

International journal of molecular sciences, 2015-04, Vol.16 (5), p.9314-9340

2015

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Control of the Restriction Point by Rb and p21

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (35), p.E8219-E8227

2018

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Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

Cell death & disease, 2018-10, Vol.9 (11), p.1100-12, Article 1100

2018

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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells

Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

Pulchranin A: First report of isolation from an endophytic fungus and its inhibitory activity on cyclin dependent kinases

Evidence that the human cell cycle is a series of uncoupled, memoryless phases

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

S‐adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity

Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

Type II Inhibitors Targeting CDK2

Fibroblast growth factor 2 induces proliferation and fibrosis via SNAI1-mediated activation of CDK2 and ZEB1 in corneal endothelium

Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells

Development of CDK2 and CDK5 Dual Degrader TMX‐2172

KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

Control of the Restriction Point by Rb and p21

Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

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