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Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease

Handbook of experimental pharmacology, 2017-01, Vol.243, p.249-269

2017

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Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

Cell stem cell, 2015-07, Vol.17 (1), p.89-100

2015

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PDE4DIP in health and diseases

Cellular signalling, 2022-06, Vol.94, p.110322-110322, Article 110322

Mani, Arya

2022

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Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (52), p.E12265-E12274

2018

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Copper regulates cyclic-AMP-dependent lipolysis

Nature chemical biology, 2016-08, Vol.12 (8), p.586

2016

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SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Nature communications, 2019-06, Vol.10 (1), p.2692-16, Article 2692

2019

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Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H 2 -histamine-receptor activation in isolated atria of transgenic mice

Naunyn-Schmiedeberg's archives of pharmacology, 2021-06, Vol.394 (6), p.1215

2021

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Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (49), p.19532-19537

2008

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Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF

Oncogene, 2013-02, Vol.32 (9), p.1121-1134

2013

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Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage

Circulation (New York, N.Y.), 2022-12, Vol.146 (23), p.1758-1778

2022

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Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy

Circulation research, 2015-04, Vol.116 (8), p.1304-1311

2015

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Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway

Journal of molecular and cellular cardiology, 2015-11, Vol.88, p.29-38

2015

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The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

Molecular and cellular biology, 2015-08, Vol.35 (16), p.2752-2760

2015

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Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure

Circulation (New York, N.Y.), 2023-04, Vol.147 (16), p.1221-1236

2023

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Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway

Diabetes (New York, N.Y.), 2015-10, Vol.64 (10), p.3355-3362

2015

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Cigarette smoke up‐regulates PDE3 and PDE4 to decrease cAMP in airway cells

British journal of pharmacology, 2018-07, Vol.175 (14), p.2988-3006

2018

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Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain

Cardiovascular research, 2019-03, Vol.115 (3), p.546-555

2019

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Cyclic GMP Signaling Is Involved in the Luteinizing Hormone-Dependent Meiotic Maturation of Mouse Oocytes

Biology of reproduction, 2009-09, Vol.81 (3), p.595-604

2009

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Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

Molecular cell, 2019-09, Vol.75 (6), p.1103-1116.e9

2019

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Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell-like Property and Metastasis in Breast Cancer

Molecular cancer therapeutics, 2020-03, Vol.19 (3), p.868-881

2020

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Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Basic & clinical pharmacology & toxicology, 2014-05, Vol.114 (5), p.365-376

2014

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Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2

The Journal of biological chemistry, 2015-03, Vol.290 (11), p.6763-6776

2015

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Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium

PloS one, 2012-10, Vol.7 (10), p.e47652-e47652

2012

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Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation

American journal of physiology. Heart and circulatory physiology, 2017-06, Vol.312 (6), p.H1224-H1237

2017

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Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

PDE4DIP in health and diseases

Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

Copper regulates cyclic-AMP-dependent lipolysis

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H 2 -histamine-receptor activation in isolated atria of transgenic mice

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF

Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage

Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy

Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism

Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure

Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway

Cigarette smoke up‐regulates PDE3 and PDE4 to decrease cAMP in airway cells

Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain

Cyclic GMP Signaling Is Involved in the Luteinizing Hormone-Dependent Meiotic Maturation of Mouse Oocytes

Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell-like Property and Metastasis in Breast Cancer

Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2

Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium

Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation

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