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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

Science (American Association for the Advancement of Science), 2017-06, Vol.356 (6342), p.1084-1087

2017

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XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

Cell death & disease, 2020-08, Vol.11 (8), p.629, Article 629

2020

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Effects of tempol and redox-cycling nitroxides in models of oxidative stress

Pharmacology & therapeutics (Oxford), 2010-05, Vol.126 (2), p.119-145

Wilcox, Christopher S

2010

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Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis

Journal of the American Chemical Society, 2009-03, Vol.131 (9), p.3291-3306

2009

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Solid-State NMR on Bacterial Cells: Selective Cell Wall Signal Enhancement and Resolution Improvement using Dynamic Nuclear Polarization

Journal of the American Chemical Society, 2013-04, Vol.135 (13), p.5105-5110

2013

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Fluorescence probes to detect lipid-derived radicals

Nature chemical biology, 2016-08, Vol.12 (8), p.608-613

2016

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Chemical Deprenylation of N 6 -Isopentenyladenosine (i 6 A) RNA

Angewandte Chemie International Edition, 2020-06, Vol.59 (26), p.10645-10650

2020

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Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474

ACS chemical biology, 2019-02, Vol.14 (2), p.192-197

2019

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TEMPO-Mediated Oxidation of Native Cellulose. The Effect of Oxidation Conditions on Chemical and Crystal Structures of the Water-Insoluble Fractions

Biomacromolecules, 2004-09, Vol.5 (5), p.1983-1989

2004

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Safety, Tolerability, and Pharmacokinetics of FAAH Inhibitor BIA 10‐2474: A Double‐Blind, Randomized, Placebo‐Controlled Study in Healthy Volunteers

Clinical pharmacology and therapeutics, 2022-02, Vol.111 (2), p.391-403

2022

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Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

Free radical biology & medicine, 2012-01, Vol.52 (2), p.497-506

2012

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Possible artefacts of antioxidant assays performed in the presence of nitroxides and nitroxide-containing nanoparticles

Analytical biochemistry, 2020-05, Vol.597, p.113698, Article 113698

2020

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Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase

ChemMedChem, 2018-10, Vol.13 (20), p.2177-2188

2018

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Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans

Journal of natural products (Washington, D.C.), 2015-07, Vol.78 (7), p.1511-1517

2015

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Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases

PloS one, 2015-07, Vol.10 (7), p.e0130442

2015

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The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.731-741

2003

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Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474

Biochemical and biophysical research communications, 2017-01, Vol.483 (1), p.502-508

2017

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Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging

Biochemical and biophysical research communications, 2017-04, Vol.485 (4), p.802-806

2017

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The Bial 10‐2474 Phase 1 Study—A Drug Development Perspective and Recommendations for Future First‐in‐Human Trials

Journal of clinical pharmacology, 2017-06, Vol.57 (6), p.690-703

Chaikin, Philip

2017

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Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl- N-tert -butylnitrone Analogues in In Vitro Ischemia Models

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.1127

2021

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Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

Brain research bulletin, 2014-02, Vol.101, p.51-56

2014

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Redox-Responsive Fluorescent Probes with Different Design Strategies

Accounts of chemical research, 2015-05, Vol.48 (5), p.1358-1368

2015

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Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain

Journal of cerebral blood flow and metabolism, 2017-11, Vol.37 (11), p.3635-3639

2017

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Synthesis of New Quinoxaline-2-carboxylate 1,4-Dioxide Derivatives as Anti-Mycobacterium tuberculosis Agents

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2019-2025

2005

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Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies

Pharmacology research & perspectives, 2024-06, Vol.12 (3), p.e1200-n/a

2024

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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

Effects of tempol and redox-cycling nitroxides in models of oxidative stress

Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis

Solid-State NMR on Bacterial Cells: Selective Cell Wall Signal Enhancement and Resolution Improvement using Dynamic Nuclear Polarization

Fluorescence probes to detect lipid-derived radicals

Chemical Deprenylation of N 6 -Isopentenyladenosine (i 6 A) RNA

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474

TEMPO-Mediated Oxidation of Native Cellulose. The Effect of Oxidation Conditions on Chemical and Crystal Structures of the Water-Insoluble Fractions

Safety, Tolerability, and Pharmacokinetics of FAAH Inhibitor BIA 10‐2474: A Double‐Blind, Randomized, Placebo‐Controlled Study in Healthy Volunteers

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

Possible artefacts of antioxidant assays performed in the presence of nitroxides and nitroxide-containing nanoparticles

Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase

Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans

Nano-Drugs Based on Nano Sterically Stabilized Liposomes for the Treatment of Inflammatory Neurodegenerative Diseases

The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474

Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging

The Bial 10‐2474 Phase 1 Study—A Drug Development Perspective and Recommendations for Future First‐in‐Human Trials

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl- N-tert -butylnitrone Analogues in In Vitro Ischemia Models

Effect of tempol on the passive avoidance and novel object recognition task in diabetic rats

Redox-Responsive Fluorescent Probes with Different Design Strategies

Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain

Synthesis of New Quinoxaline-2-carboxylate 1,4-Dioxide Derivatives as Anti-Mycobacterium tuberculosis Agents

Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies

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