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Crosstalk between PKA and PKG controls pH‐dependent host cell egress of Toxoplasma gondii

The EMBO journal, 2017-11, Vol.36 (21), p.3250-3267

2017

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Cyclic GMP-Dependent Signaling in Cardiac Myocytes

Circulation Journal, 2012, Vol.76(8), pp.1819-1825

Takimoto, Eiki

2012

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Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I

Hypertension (Dallas, Tex. 1979), 2022-05, Vol.79 (5), p.946-956

2022

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Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach

Biochemical journal, 2007-10, Vol.407 (1), p.69-77

2007

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Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3668-3681

2016

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The pleiotropic Legionella transcription factor LvbR links the Lqs and c‐di‐GMP regulatory networks to control biofilm architecture and virulence

Environmental microbiology, 2019-03, Vol.21 (3), p.1035-1053

2019

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Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

Molecular cell, 2012-05, Vol.46 (4), p.449-460

2012

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Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

Cellular signalling, 2018-01, Vol.42, p.281-291

Kelly, Michy P.

2018

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cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Proceedings of the National Academy of Sciences - PNAS, 2020-06, Vol.117 (25), p.14220-14230

2020

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Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

Nature, 2009-06, Vol.459 (7249), p.1015-1018

2009

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Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Nature communications, 2019-11, Vol.10 (1), p.5358-10, Article 5358

2019

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Crystal structure of an HD‐GYP domain cyclic‐di‐GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

Molecular microbiology, 2014-01, Vol.91 (1), p.26-38

2014

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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

Nature medicine, 2005-02, Vol.11 (2), p.214-222

2005

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Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

mBio, 2017-05, Vol.8 (3)

2017

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Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP

The Journal of biological chemistry, 2014-03, Vol.289 (10), p.6978-6990

2014

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LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3461-3466

2009

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Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

Biochemical pharmacology, 2020-06, Vol.176, p.113818-113818, Article 113818

2020

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Phosphodiesterases in neurodegenerative disorders

IUBMB life, 2012-12, Vol.64 (12), p.965-970

2012

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Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice

Neurobiology of aging, 2023-11, Vol.131, p.39-51

2023

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Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

Infection and Immunity, 2013-08, Vol.81 (8), p.2705-2713

2013

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Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway

PLoS biology, 2020-11, Vol.18 (11), p.e3000872-e3000872

2020

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Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions

Cellular and molecular life sciences : CMLS, 2017-05, Vol.74 (10), p.1883-1893

2017

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Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator

FEBS letters, 2014-12, Vol.588 (24), p.4631-4636

2014

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Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (23), p.9161-9166

2012

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Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Clinical science (1979), 2019-08, Vol.133 (15), p.1705-1720

2019

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Crosstalk between PKA and PKG controls pH‐dependent host cell egress of Toxoplasma gondii

Cyclic GMP-Dependent Signaling in Cardiac Myocytes

Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I

Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach

Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase

The pleiotropic Legionella transcription factor LvbR links the Lqs and c‐di‐GMP regulatory networks to control biofilm architecture and virulence

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Crystal structure of an HD‐GYP domain cyclic‐di‐GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP

LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

Phosphodiesterases in neurodegenerative disorders

Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway

Effects of cyclic nucleotide phosphodiesterases (PDEs) on mitochondrial skeletal muscle functions

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

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