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Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity

PloS one, 2017-08, Vol.12 (8), p.e0182022-e0182022

2017

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Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice

Peptides (New York, N.Y. : 1980), 2013-07, Vol.45, p.85-90

2013

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Colchicine in Cardiovascular Disease: In-Depth Review

Circulation (New York, N.Y.), 2022-01, Vol.145 (1), p.61-78

2022

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Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

The FEBS journal, 2016-01, Vol.283 (1), p.102-111

2016

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Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective

Drug discovery today, 2022-03, Vol.27 (3), p.759-776

2022

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Colchicine: Old and New

The American journal of medicine, 2015-05, Vol.128 (5), p.461-470

2015

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Colchicine: an ancient drug with novel applications

British journal of dermatology (1951), 2018-02, Vol.178 (2), p.350-356

2018

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Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Molecules (Basel, Switzerland), 2020-04, Vol.25 (8), p.1789

2020

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Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship

European journal of medicinal chemistry, 2020-01, Vol.185, p.111788, Article 111788

2020

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Anti-Microtubule Drugs

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1413, p.403

2016

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Mechanism of Action of Colchicine in the Treatment of Gout

Clinical therapeutics, 2014-10, Vol.36 (10), p.1465-1479

2014

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Potential anticancer role of colchicine-based derivatives: an overview

Anti-cancer drugs, 2017-03, Vol.28 (3), p.250-262

2017

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Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments

Seminars in arthritis and rheumatism, 2017-08, Vol.47 (1), p.115-120

2017

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Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Clinical and experimental pharmacology & physiology, 2021-06, Vol.48 (6), p.823-830

2021

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Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities

European journal of medicinal chemistry, 2020-09, Vol.202, p.112519, Article 112519

2020

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Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

Medicinal research reviews, 2008-01, Vol.28 (1), p.155-183

2008

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Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review

Acta pharmacologica Sinica, 2022-09, Vol.43 (9), p.2173-2190

2022

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Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?

Dalton transactions : an international journal of inorganic chemistry, 2024-07, Vol.53 (29), p.12349-12369

2024

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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Journal of molecular biology, 2014-04, Vol.426 (8), p.1848-1860

2014

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Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties

Bioorganic & medicinal chemistry letters, 2021-09, Vol.47, p.128197-128197, Article 128197

2021

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Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site

Bioorganic & medicinal chemistry letters, 2024-06, Vol.105, p.129745-129745, Article 129745

2024

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COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

In vivo (Athens), 2020-06, Vol.34 (3 Suppl), p.1567-1588

2020

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Identification of Novel β‑Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach

Journal of chemical information and modeling, 2023-10, Vol.63 (20), p.6396-6411

2023

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Colchicine and the Heart: Pushing the Envelope

Journal of the American College of Cardiology, 2013-11, Vol.62 (20), p.1817-1825

2013

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Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids

European journal of medicinal chemistry, 2017-12, Vol.141, p.51-60

2017

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Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity

Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice

Colchicine in Cardiovascular Disease: In-Depth Review

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective

Colchicine: Old and New

Colchicine: an ancient drug with novel applications

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship

Anti-Microtubule Drugs

Mechanism of Action of Colchicine in the Treatment of Gout

Potential anticancer role of colchicine-based derivatives: an overview

Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities

Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review

Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties

Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site

COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2

Identification of Novel β‑Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach

Colchicine and the Heart: Pushing the Envelope

Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids

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