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A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Molecules (Basel, Switzerland), 2020-02, Vol.25 (3), p.698

2020

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Specialized roles for cysteine cathepsins in health and disease

The Journal of clinical investigation, 2010-10, Vol.120 (10), p.3421-3431

2010

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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Journal of virology, 2018-10, Vol.92 (19)

2018

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Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Frontiers in cellular and infection microbiology, 2020-12, Vol.10, p.589505-589505

2020

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Nature communications, 2020-03, Vol.11 (1), p.1620-1620, Article 1620

2020

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Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Signal transduction and targeted therapy, 2021-03, Vol.6 (1), p.134-134, Article 134

2021

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In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection

Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3822

2020

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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Biochimica et biophysica acta, 2012-01, Vol.1824 (1), p.89-104

2012

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Cathepsin L targeting in cancer treatment

Pharmacology & therapeutics (Oxford), 2015-11, Vol.155, p.105-116

2015

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Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Parasites & vectors, 2018-03, Vol.11 (1), p.142-142, Article 142

2018

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Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

Virology (New York, N.Y.), 2019-06, Vol.532, p.22-29

2019

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Primary digestive cathepsins L of Tribolium castaneum larvae: Proteomic identification, properties, comparison with human lysosomal cathepsin L

Insect biochemistry and molecular biology, 2022-01, Vol.140, p.103679-103679, Article 103679

2022

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Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2485-2497

2017

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Role of Endogenous Cathepsin L in Muscle Protein Degradation in Olive Flounder ( Paralichthys olivaceus ) Surimi Gel

Molecules (Basel, Switzerland), 2021-03, Vol.26 (7), p.1901

2021

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Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate

Biological chemistry, 2024-05, Vol.405 (5), p.351

2024

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A humanized antibody inhibitor for cathepsin L

Protein science, 2020-09, Vol.29 (9), p.1924-1930

2020

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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

Science advances, 2020-12, Vol.6 (50)

2020

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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

Gastroenterology (New York, N.Y. 1943), 2018-02, Vol.154 (3), p.704-718.e10

2018

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Cathepsin B and L inhibitors: a patent review (2010 - present)

Expert opinion on therapeutic patents, 2017-06, Vol.27 (6), p.643-656

2017

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Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

Biochimie, 2019-11, Vol.166, p.94-102

2019

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Cathepsins L and B in Dysdercus peruvianus, Rhodnius prolixus, and Mahanarva fimbriolata. Looking for enzyme adaptations to digestion

Insect biochemistry and molecular biology, 2020-12, Vol.127, p.103488-103488, Article 103488

2020

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Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

Veterinary parasitology, 2013-08, Vol.195 (3-4), p.272-285

2013

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Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

Journal of virology, 2017-01, Vol.91 (1)

2017

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Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.227-227, Article 227

2024

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MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L

ChemMedChem, 2022-01, Vol.17 (1), p.e202100456-n/a

2022

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A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Specialized roles for cysteine cathepsins in health and disease

Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Cathepsin L targeting in cancer treatment

Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

Primary digestive cathepsins L of Tribolium castaneum larvae: Proteomic identification, properties, comparison with human lysosomal cathepsin L

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

Role of Endogenous Cathepsin L in Muscle Protein Degradation in Olive Flounder ( Paralichthys olivaceus ) Surimi Gel

Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate

A humanized antibody inhibitor for cathepsin L

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

Cathepsin B and L inhibitors: a patent review (2010 - present)

Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

Cathepsins L and B in Dysdercus peruvianus, Rhodnius prolixus, and Mahanarva fimbriolata. Looking for enzyme adaptations to digestion

Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic development

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L

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