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Cathepsins: Proteases that are vital for survival but can also be fatal

Biomedicine & pharmacotherapy, 2018-09, Vol.105, p.526-532

2018

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Specialized roles for cysteine cathepsins in health and disease

The Journal of clinical investigation, 2010-10, Vol.120 (10), p.3421-3431

2010

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Cysteine cathepsins: From structure, function and regulation to new frontiers

Biochimica et biophysica acta, 2012-01, Vol.1824 (1), p.68-88

2012

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Correction to: Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-ÎºB pathway

Journal of neuroinflammation, 2022-01, Vol.19 (1)

2022

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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Biochimica et biophysica acta, 2012-01, Vol.1824 (1), p.89-104

2012

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Emerging roles of cysteine cathepsins in disease and their potential as drug targets

Current pharmaceutical design, 2007-02, Vol.13 (4), p.387-403

2007

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Functional characterization of a cystatin A from the bat Myotis davidii

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2024-10, Vol.274, p.111003, Article 111003

2024

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Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

Journal of virology, 2018-10, Vol.92 (19)

2018

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The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

Archives of biochemistry and biophysics, 2019-07, Vol.670, p.32-42

2019

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Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Parasites & vectors, 2018-03, Vol.11 (1), p.142-142, Article 142

2018

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Quinazoline derivatives as cathepsins B, H and L inhibitors and cell proliferating agents

International journal of biological macromolecules, 2017-01, Vol.94 (Pt A), p.719-727

2017

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The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

The Journal of neuroscience, 2015-09, Vol.35 (36), p.12488-12501

2015

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A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Molecules (Basel, Switzerland), 2020-02, Vol.25 (3), p.698

2020

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Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

PloS one, 2016-11, Vol.11 (11), p.e0167428-e0167428

2016

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Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

The Journal of experimental medicine, 2008-03, Vol.205 (3), p.685-698

2008

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Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2030

2023

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Some thiocarbamoyl based novel anticathepsin agents

Bioorganic chemistry, 2020-11, Vol.104, p.104174, Article 104174

2020

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Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

Virology (New York, N.Y.), 2019-06, Vol.532, p.22-29

2019

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Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

The Journal of biological chemistry, 2019-01, Vol.294 (2), p.697-707

2019

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Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

Journal of controlled release, 2019-01, Vol.294, p.376-389

2019

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Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3582-3594

2018

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Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo

Clinical and experimental immunology, 2006-10, Vol.146 (1), p.169-180

2006

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Cathepsins L and B in Dysdercus peruvianus, Rhodnius prolixus, and Mahanarva fimbriolata. Looking for enzyme adaptations to digestion

Insect biochemistry and molecular biology, 2020-12, Vol.127, p.103488-103488, Article 103488

2020

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Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

Aging (Albany, NY.), 2021-01, Vol.13 (1), p.973-990

2021

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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

Gastroenterology (New York, N.Y. 1943), 2018-02, Vol.154 (3), p.704-718.e10

2018

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Cathepsins: Proteases that are vital for survival but can also be fatal

Specialized roles for cysteine cathepsins in health and disease

Cysteine cathepsins: From structure, function and regulation to new frontiers

Correction to: Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-ÎºB pathway

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Emerging roles of cysteine cathepsins in disease and their potential as drug targets

Functional characterization of a cystatin A from the bat Myotis davidii

Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

Cysteine peptidases of Eudiplozoon nipponicum: a broad repertoire of structurally assorted cathepsins L in contrast to the scarcity of cathepsins B in an invasive species of haematophagous monogenean of common carp

Quinazoline derivatives as cathepsins B, H and L inhibitors and cell proliferating agents

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction

Some thiocarbamoyl based novel anticathepsin agents

Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L

Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors

Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo

Cathepsins L and B in Dysdercus peruvianus, Rhodnius prolixus, and Mahanarva fimbriolata. Looking for enzyme adaptations to digestion

Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

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