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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

Nature nanotechnology, 2019-08, Vol.14 (8), p.799-809

2019

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DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Clinical cancer research, 2016-10, Vol.22 (20), p.5097-5108

2016

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Sacituzumab govitecan (IMMU‐132), an anti‐Trop‐2‐SN‐38 antibody‐drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics

Cancer, 2017-10, Vol.123 (19), p.3843-3854

2017

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Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy

ACS nano, 2017-09, Vol.11 (9), p.8838-8848

2017

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Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

Advanced materials (Weinheim), 2014-06, Vol.26 (21), p.3433-3440

2014

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The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

ACS nano, 2015-07, Vol.9 (7), p.7195-7206

2015

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Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

The Journal of clinical investigation, 2017-05, Vol.127 (5), p.2007-2018

2017

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Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect

Nature reviews. Clinical oncology, 2016-11, Vol.13 (11), p.659-673

2016

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Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

Journal of the American Chemical Society, 2012-08, Vol.134 (30), p.12668-12674

2012

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Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

World journal of gastroenterology : WJG, 2015-11, Vol.21 (43), p.12234-12248

2015

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Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer

ACS nano, 2016-02, Vol.10 (2), p.2702-2715

2016

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Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma

Journal of controlled release, 2017-08, Vol.259, p.136-148

2017

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The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (9), p.4518-4526

2020

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Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers

Bioconjugate chemistry, 2015-05, Vol.26 (5), p.919-931

2015

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Near-Infrared Light-Activated Photochemical Internalization of Reduction-Responsive Polyprodrug Vesicles for Synergistic Photodynamic Therapy and Chemotherapy

Biomacromolecules, 2017-08, Vol.18 (8), p.2571-2582

2017

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Pharmacokinetics, Safety, and Efficacy of Trastuzumab Deruxtecan with Concomitant Ritonavir or Itraconazole in Patients with HER2-Expressing Advanced Solid Tumors

Clinical cancer research, 2021-11, Vol.27 (21), p.5771-5780

2021

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Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

Journal of clinical oncology, 2016-04, Vol.34 (12), p.1368-1375

2016

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Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Journal of controlled release, 2017-02, Vol.247, p.28-54

2017

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CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3850-3854

2016

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An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Angewandte Chemie (International ed.), 2014-04, Vol.53 (17), p.4469-4474

International ed. in English, 2014

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Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)

Current medicinal chemistry, 2017-01, Vol.24 (2), p.193

2017

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Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

Advanced materials (Weinheim), 2013-08, Vol.25 (32), p.4452-4458

2013

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Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

International journal of pharmaceutics, 2018-10, Vol.549 (1-2), p.352-362

2018

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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Sacituzumab govitecan (IMMU‐132), an anti‐Trop‐2‐SN‐38 antibody‐drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics

Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy

Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer

Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers

Near-Infrared Light-Activated Photochemical Internalization of Reduction-Responsive Polyprodrug Vesicles for Synergistic Photodynamic Therapy and Chemotherapy

Pharmacokinetics, Safety, and Efficacy of Trastuzumab Deruxtecan with Concomitant Ritonavir or Itraconazole in Patients with HER2-Expressing Advanced Solid Tumors

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)

Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

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