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Methadone pharmacogenetics in vitro and in vivo: Metabolism by CYP2B6 polymorphic variants and genetic variability in paediatric disposition

British journal of clinical pharmacology, 2022-11, Vol.88 (11), p.4881-4893

2022

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Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6813-6822

2016

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes

Biochemical pharmacology, 2016-08, Vol.113, p.88-96

2016

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Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Clinical pharmacology and therapeutics, 2018-07, Vol.104 (1), p.130

2018

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Population Pharmacokinetic Model Linking Plasma and Peripheral Blood Mononuclear Cell Concentrations of Efavirenz and Its Metabolite, 8-Hydroxy-Efavirenz, in HIV Patients

Antimicrobial agents and chemotherapy, 2017-08, Vol.61 (8)

2017

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Uncoupling of Cytochrome P450 2B6 and stimulation of reactive oxygen species production in pharmacogenomic alleles affected by interethnic variability

Biochimica et biophysica acta. General subjects, 2024-05, Vol.1868 (5), p.130595-130595, Article 130595

2024

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Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection

PloS one, 2015-06, Vol.10 (6), p.e0130583-e0130583

2015

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PharmVar GeneFocus: CYP2B6

Clinical pharmacology and therapeutics, 2021-07, Vol.110 (1), p.82-97

2021

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Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Biochemical pharmacology, 2018-06, Vol.152, p.279-292

2018

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Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1390-1398

2016

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CYP2B6 Genotype and Weight Gain Differences Between Dolutegravir and Efavirenz

Clinical infectious diseases, 2021-12, Vol.73 (11), p.e3902-e3909

2021

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Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition

Antimicrobial agents and chemotherapy, 2017-01, Vol.61 (1)

2017

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Enhanced Oral Bioavailability of Efavirenz by Solid Lipid Nanoparticles : In Vitro Drug Release and Pharmacokinetics Studies

BioMed research international, 2014-01, Vol.2014 (2014), p.1-9

2014

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Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients

Journal of clinical pharmacology, 2016-12, Vol.56 (12), p.1538-1549

2016

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Psoralen, a mechanism-based inactivator of CYP2B6

Chemico-biological interactions, 2015-10, Vol.240, p.346-352

2015

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Abstract 1260 Site-Specific Isopropylation of Parent Molecule As a Way to Develop Artemisinin Long-Acting Antimalarial and AntiCytomegalovirus Formulation

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.105825, Article 105825

2024

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Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6

Molecular pharmacology, 2020-09, Vol.98 (3), p.267-279

2020

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Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype

Journal of hazardous materials, 2020-03, Vol.386, p.121904, Article 121904

2020

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Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Molecules (Basel, Switzerland), 2016-02, Vol.21 (2), p.211

2016

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Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia

Current drug metabolism, 2023-01, Vol.23 (14), p.1156-1161

2023

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Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site

Drug metabolism and disposition, 2023-03, Vol.51 (3), p.369-384

2023

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Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics

Medicine (Baltimore), 2021-07, Vol.100 (29), p.e26614-e26614

2021

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Evaluation of universal versus genotype-guided efavirenz dose reduction in pregnant women using population pharmacokinetic modelling

Journal of antimicrobial chemotherapy, 2018-01, Vol.73 (1), p.165-172

2018

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Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD)

Food and chemical toxicology, 2021-06, Vol.152, p.112175-112175, Article 112175

2021

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Methadone pharmacogenetics in vitro and in vivo: Metabolism by CYP2B6 polymorphic variants and genetic variability in paediatric disposition

Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers

Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs

Population Pharmacokinetic Model Linking Plasma and Peripheral Blood Mononuclear Cell Concentrations of Efavirenz and Its Metabolite, 8-Hydroxy-Efavirenz, in HIV Patients

Uncoupling of Cytochrome P450 2B6 and stimulation of reactive oxygen species production in pharmacogenomic alleles affected by interethnic variability

Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection

PharmVar GeneFocus: CYP2B6

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

CYP2B6 Genotype and Weight Gain Differences Between Dolutegravir and Efavirenz

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition

Enhanced Oral Bioavailability of Efavirenz by Solid Lipid Nanoparticles : In Vitro Drug Release and Pharmacokinetics Studies

Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients

Psoralen, a mechanism-based inactivator of CYP2B6

Abstract 1260 Site-Specific Isopropylation of Parent Molecule As a Way to Develop Artemisinin Long-Acting Antimalarial and AntiCytomegalovirus Formulation

Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6

Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Effects of CYP2B6 Genetic Variants on the Propofol Dose and Response among Jordanian Arabic Patients Undergoing General Anesthesia

Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site

Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics

Evaluation of universal versus genotype-guided efavirenz dose reduction in pregnant women using population pharmacokinetic modelling

Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD)

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