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GABA A receptor signalling mechanisms revealed by structural pharmacology

Nature (London), 2019-01, Vol.565 (7740), p.454

2019

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Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

Nature communications, 2020-04, Vol.11 (1), p.2070-5, Article 2070

2020

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HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

Nature (London), 2016-08, Vol.536 (7616), p.349-353

2016

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X-ray structures define human P2X(3) receptor gating cycle and antagonist action

Nature (London), 2016-10, Vol.538 (7623), p.66

2016

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Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

Immunity (Cambridge, Mass.), 2015-05, Vol.42 (5), p.815-825

2015

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In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors

Toxicology and applied pharmacology, 2013-10, Vol.272 (1), p.127-136

2013

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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

Nature (London), 2014-08, Vol.512 (7514), p.333-337

2014

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Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Nature communications, 2021-01, Vol.12 (1), p.582-582, Article 582

2021

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Structure of a human synaptic GABA A receptor

Nature (London), 2018-07, Vol.559 (7712), p.67-72

2018

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The orphan receptor GPR55 is a novel cannabinoid receptor

British journal of pharmacology, 2007-12, Vol.152 (7), p.1092-1101

2007

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Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor

The Journal of pharmacology and experimental therapeutics, 2016-01, Vol.356 (1), p.223-231

2016

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Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase

PloS one, 2014-04, Vol.9 (4), p.e94829-e94829

2014

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Synthesis, Electronic Structure, DNA and Protein Binding, DNA Cleavage, and Anticancer Activity of Fluorophore-Labeled Copper(II) Complexes

Inorganic chemistry, 2011-01, Vol.50 (2), p.545-558

2011

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Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.113, Article 113

2022

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Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

Nature chemical biology, 2016-03, Vol.12 (3), p.174-179

2016

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Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

Brain (London, England : 1878), 2013-07, Vol.136 (Pt 7), p.2217-2227

2013

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Nature communications, 2012-12, Vol.3 (1), p.1288-12, Article 1288

2012

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Human Rap1 modulates TRF2 attraction to telomeric DNA

Nucleic acids research, 2015-03, Vol.43 (5), p.2691-2700

2015

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Evidence for natural antisense transcript-mediated inhibition of microRNA function

Genome biology, 2010-05, Vol.11 (5), p.R56-R56, Article R56

2010

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Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

The Journal of biological chemistry, 2014-01, Vol.289 (2), p.942-955

2014

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Beta-Caryophyllene Is a Dietary Cannabinoid

Proceedings of the National Academy of Sciences - PNAS, 2008-07, Vol.105 (26), p.9099-9104

2008

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Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2611-2622

2014

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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

Nature chemical biology, 2013-03, Vol.9 (3), p.184-191

2013

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

Nature neuroscience, 2008-07, Vol.11 (7), p.780-789

2008

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Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

GABA A receptor signalling mechanisms revealed by structural pharmacology

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

X-ray structures define human P2X(3) receptor gating cycle and antagonist action

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Structure of a human synaptic GABA A receptor

The orphan receptor GPR55 is a novel cannabinoid receptor

Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor

Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase

Synthesis, Electronic Structure, DNA and Protein Binding, DNA Cleavage, and Anticancer Activity of Fluorophore-Labeled Copper(II) Complexes

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Human Rap1 modulates TRF2 attraction to telomeric DNA

Evidence for natural antisense transcript-mediated inhibition of microRNA function

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Beta-Caryophyllene Is a Dietary Cannabinoid

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

The binding sites for cocaine and dopamine in the dopamine transporter overlap

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