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Novel bexarotene derivatives: Synthesis and cytotoxicity evaluation for glioma cells in 2D and 3D in vitro models

European journal of pharmacology, 2020-09, Vol.883, p.173346, Article 173346

2020

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Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Journal of controlled release, 2018-09, Vol.286, p.10-19

2018

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A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-01, Vol.1189, p.123025-123025, Article 123025

2022

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Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Pharmacological research, 2020-09, Vol.159, p.104960-104960, Article 104960

2020

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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Nature communications, 2021-01, Vol.12 (1), p.688-9, Article 688

2021

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Bexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage

Experimental neurology, 2022-12, Vol.358, p.114228, Article 114228

2022

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Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

Neurobiology of disease, 2018-09, Vol.117, p.114-124

2018

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Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage

Stroke (1970), 2020-02, Vol.51 (2), p.612-618

2020

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Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

The New England journal of medicine, 2017-07, Vol.377 (1), p.62-70

2017

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Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Experimental neurology, 2019-04, Vol.314, p.111-125

2019

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Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer

Pharmacology & therapeutics (Oxford), 2023-12, Vol.252, p.108561-108561, Article 108561

2023

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Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

Molecular neurobiology, 2018-12, Vol.55 (12), p.9043-9056

2018

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Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis

European journal of medicinal chemistry, 2020-08, Vol.199, p.112425, Article 112425

2020

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Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

BMC cancer, 2018-04, Vol.18 (1), p.407-407, Article 407

2018

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Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

Molecular neurobiology, 2019-12, Vol.56 (12), p.8220-8236

2019

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Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

Neurochemical research, 2020-07, Vol.45 (7), p.1500-1509

2020

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Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

Journal of pharmaceutical sciences, 2019-02, Vol.108 (2), p.1047-1052

2019

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Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice

Nano letters, 2019-04, Vol.19 (4), p.2231-2242

2019

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Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Journal of neuroinflammation, 2019-02, Vol.16 (1), p.47-47, Article 47

2019

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GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells

Oncotarget, 2024-02, Vol.15 (1), p.124-133

2024

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The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2023-07, Vol.1868 (7), p.159329-159329, Article 159329

2023

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Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer

Cancer prevention research (Philadelphia, Pa.), 2023-01, Vol.16 (1), p.47-55

2023

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Novel bexarotene derivatives: Synthesis and cytotoxicity evaluation for glioma cells in 2D and 3D in vitro models

Bexarotene-induced hypothyroidism and dyslipidemia; a nation-wide study

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

Bexarotene enhances astrocyte phagocytosis via ABCA1-mediated pathways in a mouse model of subarachnoid hemorrhage

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury

Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Retinoid X Receptor agonists as selective modulators of the immune system for the treatment of cancer

Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

Synthesis of some steroidal mitocans of nanomolar cytotoxicity acting by apoptosis

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach

Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists: Analogs of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahyro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(4-isobutoxy-3-isopropylphenyl)amino)nicotinic Acid (NEt-4IB)

The protective role of peroxisome proliferator-activated receptor gamma in lipotoxic podocytes

Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer

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