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Shared structural mechanisms of general anaesthetics and benzodiazepines

Nature (London), 2020-09, Vol.585 (7824), p.303-308

2020

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Structure of a human synaptic GABA A receptor

Nature (London), 2018-07, Vol.559 (7712), p.67-72

2018

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Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy

Epilepsia (Copenhagen), 2015-08, Vol.56 (8), p.1246-1251

2015

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Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Journal of medicinal chemistry, 2011-06, Vol.54 (11), p.3827-3838

2011

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A scalable platform to identify fungal secondary metabolites and their gene clusters

Nature chemical biology, 2017-08, Vol.13 (8), p.895

2017

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Endozepines and their receptors: Structure, functions and pathophysiological significance

Pharmacology & therapeutics (Oxford), 2020-04, Vol.208, p.107386-107386, Article 107386

2020

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New benzodiazepines for sedation

Best practice & research. Clinical anaesthesiology, 2018-06, Vol.32 (2), p.149-164

2018

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Hooked on benzodiazepines: GABAA receptor subtypes and addiction

Trends in neurosciences (Regular ed.), 2011-04, Vol.34 (4), p.188-197

2011

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The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Drug testing and analysis, 2018-01, Vol.10 (1), p.37-53

2018

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Brain PET imaging using 11 C-flumazenil and 11 C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neuroreceptor level

Journal of cerebral blood flow and metabolism, 2024-03, Vol.44 (3), p.449-458

2024

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Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate

Analytical chemistry (Washington), 2020-08, Vol.92 (16), p.11135-11144

2020

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Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects

Drug metabolism reviews, 2017-10, Vol.49 (4), p.451-463

Dinis-Oliveira, Ricardo Jorge

2017

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Olanzapine’s effects on hypothalamic transcriptomics and kinase activity

Psychoneuroendocrinology, 2024-05, Vol.163, p.106987-106987, Article 106987

2024

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Environmental occurrence, fate and transformation of benzodiazepines in water treatment

Water research (Oxford), 2012-02, Vol.46 (2), p.355-368

2012

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Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA A receptor: In vitro and in vivo studies

British journal of pharmacology, 2021-12, Vol.178 (24), p.4842-4858

2021

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Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.E3028-E3034

2012

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Bioconcentration and behavioral effects of four benzodiazepines and their environmentally relevant mixture in wild fish

The Science of the total environment, 2020-02, Vol.702, p.134780-134780, Article 134780

2020

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Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies

European journal of pharmaceutics and biopharmaceutics, 2014-02, Vol.86 (2), p.133-144

2014

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New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6941-6958

2020

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Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2127-2139

2019

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Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

European journal of medicinal chemistry, 2019-11, Vol.182, p.111670-111670, Article 111670

2019

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Sorption, plant uptake and metabolism of benzodiazepines

The Science of the total environment, 2018-07, Vol.628-629, p.18-25

2018

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A Benzodiazepine Ligand with Improved GABA A Receptor α 5-Subunit Selectivity Driven by Interactions with Loop C

Molecular pharmacology, 2021-01, Vol.99 (1), p.39-48

2021

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Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs

Drug metabolism and disposition, 2022-06, Vol.50 (6), p.741-749

2022

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Synthesis and Characterization of a Novel γ‑Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10800-10806

2016

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Shared structural mechanisms of general anaesthetics and benzodiazepines

Structure of a human synaptic GABA A receptor

Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

A scalable platform to identify fungal secondary metabolites and their gene clusters

Endozepines and their receptors: Structure, functions and pathophysiological significance

New benzodiazepines for sedation

Hooked on benzodiazepines: GABAA receptor subtypes and addiction

The emergence of new psychoactive substance (NPS) benzodiazepines: A review

Brain PET imaging using 11 C-flumazenil and 11 C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neuroreceptor level

Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody–Drug Conjugate

Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects

Olanzapine’s effects on hypothalamic transcriptomics and kinase activity

Environmental occurrence, fate and transformation of benzodiazepines in water treatment

Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA A receptor: In vitro and in vivo studies

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

Bioconcentration and behavioral effects of four benzodiazepines and their environmentally relevant mixture in wild fish

Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies

New Broad-Spectrum Antibiotics Containing a Pyrrolobenzodiazepine Ring with Activity against Multidrug-Resistant Gram-Negative Bacteria

Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)

Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo

Sorption, plant uptake and metabolism of benzodiazepines

A Benzodiazepine Ligand with Improved GABA A Receptor α 5-Subunit Selectivity Driven by Interactions with Loop C

Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs

Synthesis and Characterization of a Novel γ‑Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy

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