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Idarucizumab for Dabigatran Reversal

The New England journal of medicine, 2015-08, Vol.373 (6), p.511-520

2015

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The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients: The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)

Journal of the American College of Cardiology, 2014-02, Vol.63 (4), p.321-328

2014

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Perioperative Management of Dabigatran: A Prospective Cohort Study

Circulation (New York, N.Y.), 2015-07, Vol.132 (3), p.167-173

2015

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Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease

Thrombosis and haemostasis, 2013-04, Vol.109 (4), p.596

2013

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Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trial

Journal of thrombosis and haemostasis, 2011-11, Vol.9 (11), p.2168-2175

2011

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The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.386

2008

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The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

British journal of clinical pharmacology, 2007-09, Vol.64 (3), p.292-303

2007

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Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis

Journal of gastroenterology, 2018-04, Vol.53 (4), p.557-565

2018

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Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model

Journal of thrombosis and haemostasis, 2012-09, Vol.10 (9), p.1841-1848

2012

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Development of benzimidazole derivatives as efficient matrices for the analysis of acidic small‐molecule compounds using matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry in negative ion mode

Rapid communications in mass spectrometry, 2024-07, Vol.38 (13), p.e9751-n/a

2024

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Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model

Critical care (London, England), 2014-01, Vol.18 (1), p.R27-R27

2014

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A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN)

The American heart journal, 2012-06, Vol.163 (6), p.931-937.e1

2012

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Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

Circulation (New York, N.Y.), 2013-04, Vol.127 (13), p.1404-1412

2013

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Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding

Blood, 2012-03, Vol.119 (9), p.2172-2174

2012

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Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran

Blood coagulation & fibrinolysis, 2012-03, Vol.23 (2), p.138-143

2012

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Pharmacokinetics and Pharmacodynamics of the Direct Oral Thrombin Inhibitor Dabigatran in Healthy Elderly Subjects

Clinical pharmacokinetics, 2008, Vol.47 (1), p.47-59

2008

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A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects

Journal of pharmaceutical sciences, 2018-06, Vol.107 (6), p.1724-1730

2018

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Use of Thromboelastography (TEG) for Detection of New Oral Anticoagulants

Archives of pathology & laboratory medicine (1976), 2015-05, Vol.139 (5), p.665-673

2015

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Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism

Journal of controlled release, 2011-01, Vol.149 (2), p.168-174

2011

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Development and validation of a novel evaporation setup-assisted TLC method with fluorescence detection for determination of flibanserin in pharmaceutical and biological samples

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-04, Vol.1195, p.123204-123204, Article 123204

2022

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Routine coagulation assays underestimate levels of antithrombin‐dependent drugs but not of direct anticoagulant drugs in plasma from patients with cirrhosis

British journal of haematology, 2013-12, Vol.163 (5), p.666-673

2013

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Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study

Blood, 2008-06, Vol.111 (11), p.5403-5410

2008

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Bilastine vs. hydroxyzine: occupation of brain histamine H1‐receptors evaluated by positron emission tomography in healthy volunteers

British journal of clinical pharmacology, 2014-11, Vol.78 (5), p.970-980

2014

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Dabigatran Etexilate in Atrial Fibrillation Patients With Severe Renal Impairment: Dose Identification Using Pharmacokinetic Modeling and Simulation

Journal of clinical pharmacology, 2012-09, Vol.52 (9), p.1373-1378

2012

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Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects

Antimicrobial agents and chemotherapy, 2018-03, Vol.62 (3)

2018

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Idarucizumab for Dabigatran Reversal

The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients: The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)

Perioperative Management of Dabigatran: A Prospective Cohort Study

Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease

Population pharmacokinetic analysis of the oral thrombin inhibitor dabigatran etexilate in patients with non‐valvular atrial fibrillation from the RE‐LY trial

The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

Efficacy and safety of glecaprevir/pibrentasvir in Japanese patients with chronic genotype 1 hepatitis C virus infection with and without cirrhosis

Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model

Development of benzimidazole derivatives as efficient matrices for the analysis of acidic small‐molecule compounds using matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry in negative ion mode

Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model

A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN)

Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding

Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding

Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran

Pharmacokinetics and Pharmacodynamics of the Direct Oral Thrombin Inhibitor Dabigatran in Healthy Elderly Subjects

A Phase 1 Study to Evaluate the Effect of Crushing, Cutting Into Half, or Grinding of Glecaprevir/Pibrentasvir Tablets on Exposures in Healthy Subjects

Use of Thromboelastography (TEG) for Detection of New Oral Anticoagulants

Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism

Development and validation of a novel evaporation setup-assisted TLC method with fluorescence detection for determination of flibanserin in pharmaceutical and biological samples

Routine coagulation assays underestimate levels of antithrombin‐dependent drugs but not of direct anticoagulant drugs in plasma from patients with cirrhosis

Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study

Bilastine vs. hydroxyzine: occupation of brain histamine H1‐receptors evaluated by positron emission tomography in healthy volunteers

Dabigatran Etexilate in Atrial Fibrillation Patients With Severe Renal Impairment: Dose Identification Using Pharmacokinetic Modeling and Simulation

Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects

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