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Anti‐apoptotic protein BCL‐XL as a therapeutic vulnerability in gastric cancer

Animal models and experimental medicine, 2023-06, Vol.6 (3), p.245-254

2023

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Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

European journal of medicinal chemistry, 2020-04, Vol.192, p.112186-112186, Article 112186

2020

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Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

European journal of medicinal chemistry, 2020-08, Vol.199, p.112397-112397, Article 112397

2020

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Abstract 1209 Structural And Biochemical Studies Of Proteolysis-Targeting Chimera (PROTAC) Against Oncogenic Anti-Apoptotic Proteins, BCL-xl And Bcl-2

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.106068, Article 106068

2024

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Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis

The FEBS journal, 2011-02, Vol.278 (3), p.403-413

2011

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Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

Chembiochem : a European journal of chemical biology, 2022-06, Vol.23 (12), p.e202100689-n/a

2022

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VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease

Cell calcium (Edinburgh), 2018-01, Vol.69, p.81-100

2018

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Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells

Advanced pharmaceutical bulletin, 2015-09, Vol.5 (3), p.351-359

2015

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Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Molecular cell, 2020-02, Vol.77 (4), p.901-912.e9

2020

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Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl‐xL ubiquitination and degradation

Journal of thrombosis and haemostasis, 2022-12, Vol.20 (12), p.2972-2987

2022

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Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

Cancer letters, 2024-11, Vol.604, p.217240, Article 217240

2024

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Targeting BCL-2 family proteins using BH3 mimetic drugs for cancer therapy: A systematic review of randomized clinical trials

Medicine in drug discovery, 2024-12, Vol.24, p.100199, Article 100199

2024

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Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Neurobiology of disease, 2018-08, Vol.116, p.39-52

2018

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Bcl‐xL represents a therapeutic target in Philadelphia negative myeloproliferative neoplasms

Journal of cellular and molecular medicine, 2020-09, Vol.24 (18), p.10978-10986

2020

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Up‐regulation of hsa‐miR‐221‐3p induced by UVB affects proliferation and apoptosis of keratinocytes via Bcl‐xL/Bax pathway

Photodermatology, photoimmunology & photomedicine, 2021-07, Vol.37 (4), p.269-277

2021

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The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

Pharmacology & therapeutics (Oxford), 2022-02, Vol.230, p.107943-107943, Article 107943

Basu, Alakananda

2022

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Bcl-xL deamidation is regulated by multiple ion transporters and is intramolecularly catalyzed

Biochimica et biophysica acta. Molecular cell research, 2018-07, Vol.1865 (7), p.995-1001

2018

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Resistance to BCL-2 Inhibitors

Clinical lymphoma, myeloma and leukemia, 2021-09, Vol.21, p.S78-S79

Tam, Constantine S.

2021

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Bcl-XL: A multifunctional anti-apoptotic protein

Pharmacological research, 2020-01, Vol.151, p.104547, Article 104547

2020

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It's time to die: BH3 mimetics in solid tumors

Biochimica et biophysica acta. Molecular cell research, 2021-04, Vol.1868 (5), p.118987-118987, Article 118987

2021

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Interleukin 8 mediates bcl‐xL‐induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

International journal of cancer, 2018-02, Vol.142 (3), p.584-596

2018

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Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism

The FEBS journal, 2021-06, Vol.288 (11), p.3547-3569

2021

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Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer

European journal of medicinal chemistry, 2022-04, Vol.233, p.114198-114198, Article 114198

2022

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ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling

Circulation research, 2016-12, Vol.119 (12), p.1296-1312

2016

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LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL

Brain research, 2019-03, Vol.1707, p.90-98

2019

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Anti‐apoptotic protein BCL‐XL as a therapeutic vulnerability in gastric cancer

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

Abstract 1209 Structural And Biochemical Studies Of Proteolysis-Targeting Chimera (PROTAC) Against Oncogenic Anti-Apoptotic Proteins, BCL-xl And Bcl-2

Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis

Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease

Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl‐xL ubiquitination and degradation

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

Targeting BCL-2 family proteins using BH3 mimetic drugs for cancer therapy: A systematic review of randomized clinical trials

Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Bcl‐xL represents a therapeutic target in Philadelphia negative myeloproliferative neoplasms

Up‐regulation of hsa‐miR‐221‐3p induced by UVB affects proliferation and apoptosis of keratinocytes via Bcl‐xL/Bax pathway

The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

Bcl-xL deamidation is regulated by multiple ion transporters and is intramolecularly catalyzed

Resistance to BCL-2 Inhibitors

Bcl-XL: A multifunctional anti-apoptotic protein

It's time to die: BH3 mimetics in solid tumors

Interleukin 8 mediates bcl‐xL‐induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

Pharmacological preconditioning protects from ischemia/reperfusion‐induced apoptosis by modulating Bcl‐xL expression through a ROS‐dependent mechanism

Cationic liposomes co-deliver chemotherapeutics and siRNA for the treatment of breast cancer

ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling

LncRNA NEAT1 facilitates survival and angiogenesis in oxygen-glucose deprivation (OGD)-induced brain microvascular endothelial cells (BMECs) via targeting miR-377 and upregulating SIRT1, VEGFA, and BCL-XL

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