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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Nature (London), 2015-10, Vol.526 (7573), p.443-447

2015

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

Lancet neurology, 2014-03, Vol.13 (3), p.319-329

2014

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Computational Modeling of β‑Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches

Journal of chemical information and modeling, 2016-10, Vol.56 (10), p.1936-1949

2016

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Malaria parasite plasmepsins: More than just plain old degradative pepsins

The Journal of biological chemistry, 2020-06, Vol.295 (25), p.8425-8441

2020

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Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

Biochimica et biophysica acta, 2013-12, Vol.1828 (12), p.2828-2839

2013

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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

Science translational medicine, 2011-05, Vol.3 (84), p.84ra43

2011

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BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

Trends in neurosciences (Regular ed.), 2016-03, Vol.39 (3), p.158-169

2016

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Brain‐Penetration and Neuron‐Targeting DNA Nanoflowers Co‐Delivering miR‐124 and Rutin for Synergistic Therapy of Alzheimer's Disease

Small (Weinheim an der Bergstrasse, Germany), 2022-04, Vol.18 (14), p.e2107534-n/a

2022

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Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Science translational medicine, 2014-11, Vol.6 (261), p.261ra154

2014

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Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

The Journal of clinical investigation, 2013-01, Vol.123 (1), p.224-235

2013

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Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

Nature (London), 2010-02, Vol.463 (7281), p.632-636

2010

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The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1

The Journal of neuroscience, 2008-01, Vol.28 (5), p.1213-1223

2008

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Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

Science (American Association for the Advancement of Science), 2016-02, Vol.351 (6275), p.876-880

2016

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Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

Current opinion in neurobiology, 2022-02, Vol.72, p.101-110

2022

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An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome

The EMBO journal, 2020-10, Vol.39 (20), p.e105693-n/a

2020

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Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth

Scientific reports, 2016-03, Vol.6 (1), p.23575-23575, Article 23575

2016

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BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

Molecules (Basel, Switzerland), 2017-10, Vol.22 (10), p.1723

Koelsch, Gerald

2017

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

The Journal of neuroscience, 2007-04, Vol.27 (14), p.3639-3649

2007

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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

The Journal of cell biology, 2019-02, Vol.218 (2), p.644-663

2019

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Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

Scientific reports, 2017-06, Vol.7 (1), p.2908-15, Article 2908

2017

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pH-Dependent Population Shift Regulates BACE1 Activity and Inhibition

Journal of the American Chemical Society, 2015-08, Vol.137 (30), p.9540-9543

2015

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In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

Chemico-biological interactions, 2024-05, Vol.395, p.111006-111006, Article 111006

2024

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qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X‑Ray Electron Density Maps

Journal of medicinal chemistry, 2018-12, Vol.61 (24), p.11183-11198

2018

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Extracellular proteinases of Candida species pathogenic yeasts

Molecular oral microbiology, 2018-04, Vol.33 (2), p.113-124

2018

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It's good to know what to BACE the specificity of your inhibitors on

The Journal of clinical investigation, 2024-08, Vol.134 (16), p.1-4

2024

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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Computational Modeling of β‑Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches

Malaria parasite plasmepsins: More than just plain old degradative pepsins

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

Brain‐Penetration and Neuron‐Targeting DNA Nanoflowers Co‐Delivering miR‐124 and Rutin for Synergistic Therapy of Alzheimer's Disease

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome

Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

pH-Dependent Population Shift Regulates BACE1 Activity and Inhibition

In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X‑Ray Electron Density Maps

Extracellular proteinases of Candida species pathogenic yeasts

It's good to know what to BACE the specificity of your inhibitors on

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