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Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

British journal of pharmacology, 2014-06, Vol.171 (11), p.2705-2725

2014

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NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

PloS one, 2023-04, Vol.18 (4), p.e0283726-e0283726

2023

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Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Molecular carcinogenesis, 2018-04, Vol.57 (4), p.549-558

2018

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Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

Molecular carcinogenesis, 2022-05, Vol.61 (5), p.481-493

2022

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Arylamine N‐acetyltransferases: a structural perspective

British journal of pharmacology, 2013-06, Vol.169 (4), p.748-760

2013

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The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog

World journal of microbiology & biotechnology, 2019-11, Vol.35 (11), p.174-18, Article 174

2019

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Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells

Toxicology and applied pharmacology, 2022-05, Vol.442, p.115993-115993, Article 115993

2022

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Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells

Journal of cancer research and clinical oncology, 2023-07, Vol.149 (8), p.5047-5060

2023

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Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

Archives of toxicology, 2022-02, Vol.96 (2), p.511-524

2022

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CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Scientific reports, 2020-06, Vol.10 (1), p.9804, Article 9804

2020

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Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex

The international journal of biochemistry & cell biology, 2019-05, Vol.110, p.84-90

2019

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N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances

Archives of toxicology, 2023-01, Vol.97 (1), p.189-199

2023

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A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

FEBS letters, 2019-04, Vol.593 (8), p.831-841

2019

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Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Molecular carcinogenesis, 2018-11, Vol.57 (11), p.1458-1466

2018

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Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

Scientific reports, 2020-05, Vol.10 (1), p.7566, Article 7566

2020

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Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability

PloS one, 2018-03, Vol.13 (3), p.e0193560-e0193560

2018

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Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

BMC cancer, 2017-03, Vol.17 (1), p.233-11, Article 233

2017

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Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study

In vivo (Athens), 2023-05, Vol.37 (3), p.1129-1144

2023

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A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

Antimicrobial agents and chemotherapy, 2016-10, Vol.60 (10), p.6134-6145

2016

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Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human

Scientific reports, 2019-07, Vol.9 (1), p.10937-15, Article 10937

2019

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Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Acta crystallographica. Section D, Biological crystallography., 2014-11, Vol.70 (11), p.3066-3079

2014

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Arylamine N-acetyltransferase 1: a novel drug target in cancer development

Pharmacological reviews, 2012-01, Vol.64 (1), p.147-165

2012

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Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Cell reports (Cambridge), 2020-06, Vol.31 (9), p.107715-107715, Article 107715

2020

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Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

Archives of toxicology, 2021-01, Vol.95 (1), p.311-319

2021

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Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

Arylamine N‐acetyltransferases: a structural perspective

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog

Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells

Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex

N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances

A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study

A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition

Arylamine N-acetyltransferase 1: a novel drug target in cancer development

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

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