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Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

The Journal of neuroscience, 2017-12, Vol.37 (49), p.11947-11966

2017

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Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription

The Journal of biological chemistry, 2014-07, Vol.289 (29), p.20182-20191

2014

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EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Nature communications, 2015-12, Vol.6 (1), p.8997-8997, Article 8997

2015

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Persistence of Aβ seeds in APP null mouse brain

Nature neuroscience, 2015-11, Vol.18 (11), p.1559-1561

2015

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Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein

Journal of neurochemistry, 2008-02, Vol.104 (3), p.683-695

2008

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Neuron–astrocyte signaling is preserved in the aging brain

Glia, 2017-04, Vol.65 (4), p.569-580

2017

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APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

The EMBO journal, 2011-06, Vol.30 (11), p.2266-2280

2011

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APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions

PloS one, 2014-09, Vol.9 (9), p.e108576-e108576

2014

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Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Neurotherapeutics, 2018-10, Vol.15 (4), p.1055-1062

2018

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Impaired theta-gamma coupling in APP-deficient mice

Scientific reports, 2016-02, Vol.6 (1), p.21948-21948, Article 21948

2016

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Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway

The Journal of neuroscience, 2009-08, Vol.29 (33), p.10405-10409

2009

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Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Neuron (Cambridge, Mass.), 2007-10, Vol.56 (1), p.66-78

2007

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

The EMBO journal, 2004-10, Vol.23 (20), p.4106-4115

2004

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Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease

Journal of neurochemistry, 2011-03, Vol.116 (5), p.916-925

2011

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Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

Behavioural brain research, 2015-03, Vol.281, p.32-42

2015

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Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

The Journal of neuroscience, 2012-08, Vol.32 (33), p.11390-11395

2012

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Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease

The Journal of neuroscience, 2005-10, Vol.25 (42), p.9694-9703

2005

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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

EMBO reports, 2006-07, Vol.7 (7), p.739-745

2006

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APPsα rescues impaired Ca 2+ homeostasis in APP- and APLP2-deficient hippocampal neurons

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (26)

2021

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice

The Journal of neuroscience, 2007-07, Vol.27 (29), p.7817-7826

2007

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Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

Cell death & disease, 2014-08, Vol.5 (8), p.e1391-e1391

2014

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Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

Neuroscience, 2010-08, Vol.169 (1), p.344-356

2010

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Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology

Frontiers in immunology, 2020-08, Vol.11, p.1781-1781

2020

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A highly expressed miR-101 isomiR is a functional silencing small RNA

BMC genomics, 2013-02, Vol.14 (1), p.104-104, Article 104

2013

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Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease

Drugs (New York, N.Y.), 2012, Vol.72 (1), p.49-66

de la Monte, Suzanne M.

2012

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Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Persistence of Aβ seeds in APP null mouse brain

Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein

Neuron–astrocyte signaling is preserved in the aging brain

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Impaired theta-gamma coupling in APP-deficient mice

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway

Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease

Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

APPsα rescues impaired Ca 2+ homeostasis in APP- and APLP2-deficient hippocampal neurons

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC-Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology

A highly expressed miR-101 isomiR is a functional silencing small RNA

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease

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