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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

Nature (London), 2015-10, Vol.526 (7573), p.443-447

2015

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An atomic structure of human γ-secretase

Nature (London), 2015-09, Vol.525 (7568), p.212-217

2015

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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

Science translational medicine, 2011-05, Vol.3 (84), p.84ra43

2011

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Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

The EMBO journal, 2019-12, Vol.38 (23), p.e102345-n/a

2019

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The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

European journal of cell biology, 2011-06, Vol.90 (6), p.527-535

2011

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γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

Science (American Association for the Advancement of Science), 2009-05, Vol.324 (5927), p.639-642

2009

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Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease

The Journal of clinical investigation, 2013-06, Vol.123 (6), p.2523-2538

2013

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

The Journal of neuroscience, 2007-04, Vol.27 (14), p.3639-3649

2007

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ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration

The Journal of immunology (1950), 2017-07, Vol.199 (2), p.666-676

2017

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Flavonoids as BACE1 inhibitors: QSAR modelling, screening and in vitro evaluation

International journal of biological macromolecules, 2020-12, Vol.165 (Pt A), p.1323-1330

2020

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Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia

Stroke (1970), 2011-09, Vol.42 (9), p.2589-2594

2011

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Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

The Journal of biological chemistry, 2017-08, Vol.292 (32), p.13258-13270

2017

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

Lancet neurology, 2014-03, Vol.13 (3), p.319-329

2014

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Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?

The Journal of biological chemistry, 2018-10, Vol.293 (40), p.15419-15428

2018

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Structure and Function of the γ‑Secretase Complex

Biochemistry (Easton), 2019-07, Vol.58 (27), p.2953-2966

Wolfe, Michael S

2019

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γ-Secretase inhibitors and modulators

Biochimica et biophysica acta, 2013-12, Vol.1828 (12), p.2898-2907

2013

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Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

The Journal of clinical investigation, 2013-01, Vol.123 (1), p.224-235

2013

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Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

Cell reports (Cambridge), 2019-07, Vol.28 (3), p.655-669.e5

2019

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Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Nature neuroscience, 2019-07, Vol.22 (7), p.1075-1088

2019

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Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

Current opinion in neurobiology, 2022-02, Vol.72, p.101-110

2022

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γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

The Journal of biological chemistry, 2014-02, Vol.289 (6), p.3276-3287

2014

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Computational Modeling of β‑Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches

Journal of chemical information and modeling, 2016-10, Vol.56 (10), p.1936-1949

2016

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BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

Molecules (Basel, Switzerland), 2017-10, Vol.22 (10), p.1723

Koelsch, Gerald

2017

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The many substrates of presenilin/γ-secretase

Journal of Alzheimer's disease, 2011-01, Vol.25 (1), p.3-28

2011

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Brain‐Penetration and Neuron‐Targeting DNA Nanoflowers Co‐Delivering miR‐124 and Rutin for Synergistic Therapy of Alzheimer's Disease

Small (Weinheim an der Bergstrasse, Germany), 2022-04, Vol.18 (14), p.e2107534-n/a

2022

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η-Secretase processing of APP inhibits neuronal activity in the hippocampus

An atomic structure of human γ-secretase

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration

Flavonoids as BACE1 inhibitors: QSAR modelling, screening and in vitro evaluation

Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?

Structure and Function of the γ‑Secretase Complex

γ-Secretase inhibitors and modulators

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

Computational Modeling of β‑Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

The many substrates of presenilin/γ-secretase

Brain‐Penetration and Neuron‐Targeting DNA Nanoflowers Co‐Delivering miR‐124 and Rutin for Synergistic Therapy of Alzheimer's Disease

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