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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

Nature chemical biology, 2016-10, Vol.12 (10), p.838-844

2016

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International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Pharmacological reviews, 2017-04, Vol.69 (2), p.93-139

2017

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Comparative electrostatic analysis of adenylyl cyclase for isoform dependent regulation properties

Proteins, structure, function, and bioinformatics, 2016-12, Vol.84 (12), p.1844-1858

2016

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Evolutionary drivers of thermoadaptation in enzyme catalysis

Science (American Association for the Advancement of Science), 2017-01, Vol.355 (6322), p.289-294

2017

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Adenylate cyclases: Receivers, transducers, and generators of signals

Cellular signalling, 2018-06, Vol.46, p.135-144

2018

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Structure-guided design and functional characterization of an artificial red light–regulated guanylate/adenylate cyclase for optogenetic applications

The Journal of biological chemistry, 2018-06, Vol.293 (23), p.9078-9089

2018

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Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria

Journal of bacteriology, 2019-01, Vol.201 (1)

2019

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Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

Biochimica et biophysica acta, 2014-12, Vol.1842 (12), p.2535-2547

Steegborn, Clemens

2014

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Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Nature communications, 2018-05, Vol.9 (1), p.2046-15, Article 2046

2018

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Functional Non-Nucleoside Adenylyl Cyclase Inhibitors

Chemical biology & drug design, 2015-05, Vol.85 (5), p.633-637

2015

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Structural Insights into the Process of GPCR-G Protein Complex Formation

Cell, 2019-05, Vol.177 (5), p.1243-1251.e12

2019

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Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems

Journal of molecular biology, 2006-09, Vol.362 (4), p.623-639

2006

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Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

Journal of molecular biology, 2017-05, Vol.429 (9), p.1336-1351

2017

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Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications

The Journal of biological chemistry, 2010-12, Vol.285 (53), p.41501-41508

2010

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Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling

Molecular pharmacology, 2009-11, Vol.76 (5), p.935-941

Dessauer, Carmen W

2009

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AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals

The Journal of biological chemistry, 2020-10, Vol.295 (42), p.14250-14259

2020

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Chromophore–Protein Interplay during the Phytochrome Photocycle Revealed by Step-Scan FTIR Spectroscopy

Journal of the American Chemical Society, 2018-10, Vol.140 (39), p.12396-12404

2018

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Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices

International journal of molecular sciences, 2024-09, Vol.25 (17), p.9535

2024

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Intracellular cAMP signaling by soluble adenylyl cyclase

Kidney international, 2011-06, Vol.79 (12), p.1277-1288

2011

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Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP

Cell, 2018-05, Vol.173 (5), p.1254-1264.e11

2018

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A Photochromic Histidine Kinase Rhodopsin (HKR1) That Is Bimodally Switched by Ultraviolet and Blue Light

The Journal of biological chemistry, 2012-11, Vol.287 (47), p.40083-40090

2012

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Soluble adenylyl cyclase coordinates intracellular pH homeostasis and biomineralization in calcifying cells of a marine animal

American Journal of Physiology: Cell Physiology, 2023-03, Vol.324 (3), p.C777-C786

2023

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Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.E9821-E9828

2017

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Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

Molecular nutrition & food research, 2015-08, Vol.59 (8), p.1443-1457

2015

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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia

Nature structural & molecular biology, 2024-08, Vol.31 (8), p.1189-1197

2024

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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Comparative electrostatic analysis of adenylyl cyclase for isoform dependent regulation properties

Evolutionary drivers of thermoadaptation in enzyme catalysis

Adenylate cyclases: Receivers, transducers, and generators of signals

Structure-guided design and functional characterization of an artificial red light–regulated guanylate/adenylate cyclase for optogenetic applications

Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Functional Non-Nucleoside Adenylyl Cyclase Inhibitors

Structural Insights into the Process of GPCR-G Protein Complex Formation

Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems

Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

Natural and Engineered Photoactivated Nucleotidyl Cyclases for Optogenetic Applications

Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling

AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals

Chromophore–Protein Interplay during the Phytochrome Photocycle Revealed by Step-Scan FTIR Spectroscopy

Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices

Intracellular cAMP signaling by soluble adenylyl cyclase

Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP

A Photochromic Histidine Kinase Rhodopsin (HKR1) That Is Bimodally Switched by Ultraviolet and Blue Light

Soluble adenylyl cyclase coordinates intracellular pH homeostasis and biomineralization in calcifying cells of a marine animal

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia

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