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Två genombrott i behandling av typ 2-diabetes. Både receptoragonist och enzymhämmare har nu nått kliniken

Läkartidningen, 2007, Vol.104 (49-50), p.3763

Ahrén, Bo

2007

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DPP-4 inhibitors

Baillière's Best Practice & Research in Clinical Endocrinology & Metabolism, 2007-12, Vol.21 (4), p.517-533

Ahrén, Bo, MD, PhD

2007

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Mechanically induced chemiluminescence from polymers incorporating a 1,2-dioxetane unit in the main chain

Nature chemistry, 2012-06, Vol.4 (7), p.559

2012

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High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

The Lancet infectious diseases, 2017-01, Vol.17 (1), p.39-49

2017

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The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Chemical reviews, 2013-05, Vol.113 (5), p.3516-3604

2013

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Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes

The journal of clinical endocrinology and metabolism, 2004-05, Vol.89 (5), p.2078-2084

2004

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Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan

Annals of the rheumatic diseases, 2019-10, Vol.78 (10), p.1305

2019

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Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial

Circulation (New York, N.Y.), 2014-10, Vol.130 (18), p.1579-1588

2014

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Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

The New England journal of medicine, 2013-10, Vol.369 (14), p.1317-1326

2013

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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Cell reports (Cambridge), 2017-08, Vol.20 (7), p.1692-1704

2017

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Adamantane - A Lead Structure for Drugs in Clinical Practice

Current medicinal chemistry, 2016-08, Vol.23 (29), p.3245

2016

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Unusual architecture of the p7 channel from hepatitis C virus

Nature (London), 2013-06, Vol.498 (7455), p.521-525

2013

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Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial

Diabetes care, 2017-01, Vol.40 (1), p.69-76

2017

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Malaria biology and disease pathogenesis: insights for new treatments

Nature medicine, 2013-02, Vol.19 (2), p.156-167

2013

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Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)

Annals of the rheumatic diseases, 2019-10, Vol.78 (10), p.1320

2019

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Highly Efficient, Organocatalytic Aerobic Alcohol Oxidation

Journal of the American Chemical Society, 2011-05, Vol.133 (17), p.6497-6500

2011

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Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin

Diabetes care, 2015-03, Vol.38 (3), p.376-383

2015

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Insights into the κ-P,N Coordination of 1,3,5-Triaza-7-phosphaadamantane and Derivatives: κ-P,N-Heterometallic Complexes and a 15 N Nuclear Magnetic Resonance Survey

Inorganic chemistry, 2022-04, Vol.61 (15), p.5779-5791

2022

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A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors

Clinical cancer research, 2017-08, Vol.23 (16), p.4642-4650

2017

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Efficacy and safety of the oral Janus kinase inhibitor peficitinib (ASP015K) monotherapy in patients with moderate to severe rheumatoid arthritis in Japan: a 12-week, randomised, double-blind, placebo-controlled phase IIb study

Annals of the rheumatic diseases, 2016-06, Vol.75 (6), p.1057-1064

2016

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Chemistry of Bridged Lactams and Related Heterocycles

Chemical reviews, 2013-08, Vol.113 (8), p.5701-5765

2013

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Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

The Lancet infectious diseases, 2016-01, Vol.16 (1), p.61-69

2016

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NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

Science translational medicine, 2016-04, Vol.8 (334), p.334ra51

2016

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Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

Angewandte Chemie International Edition, 2021-03, Vol.60 (10), p.5429-5435

International ed. in English, 2021

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Två genombrott i behandling av typ 2-diabetes. Både receptoragonist och enzymhämmare har nu nått kliniken

DPP-4 inhibitors

Mechanically induced chemiluminescence from polymers incorporating a 1,2-dioxetane unit in the main chain

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes

Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan

Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial

Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Adamantane - A Lead Structure for Drugs in Clinical Practice

Unusual architecture of the p7 channel from hepatitis C virus

Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial

Malaria biology and disease pathogenesis: insights for new treatments

Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)

Highly Efficient, Organocatalytic Aerobic Alcohol Oxidation

Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin

Insights into the κ-P,N Coordination of 1,3,5-Triaza-7-phosphaadamantane and Derivatives: κ-P,N-Heterometallic Complexes and a 15 N Nuclear Magnetic Resonance Survey

A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors

Efficacy and safety of the oral Janus kinase inhibitor peficitinib (ASP015K) monotherapy in patients with moderate to severe rheumatoid arthritis in Japan: a 12-week, randomised, double-blind, placebo-controlled phase IIb study

Chemistry of Bridged Lactams and Related Heterocycles

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

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