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International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel

Pharmacological reviews, 2015-01, Vol.67 (1), p.1-35

2015

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Photomodulation of the ASIC1a acidic pocket destabilizes the open state

Protein science, 2023-11, Vol.32 (11), p.e4800-n/a

2023

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ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters

The FEBS journal, 2017-02, Vol.284 (4), p.525-545

Hanukoglu, Israel

2017

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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.3750-3755

2017

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Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.3768-3773

2017

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The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity

eLife, 2020-06, Vol.9

2020

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Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss

American Journal of Physiology: Cell Physiology, 2014-08, Vol.307 (3), p.C255-C265

2014

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Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation

BMB Reports, 2013, 46(6), , pp.295-304

2013

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Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

Neuropharmacology, 2015-07, Vol.94, p.19-35

2015

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Acid-Sensing Ion Channels Structural Aspects, Pathophysiological Importance and Experimental Mutational Data Available Across Various Species to Target Human ASIC1

Current drug targets, 2019-01, Vol.20 (1), p.111-121

2019

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Genetic or Pharmacological Ablation of Acid-Sensing Ion Channel 1a (ASIC1a) Is Not Neuroprotective in a Mouse Model of Spinal Cord Injury

Journal of neurotrauma, 2024-05, Vol.41 (9-10), p.1007-1019

2024

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Oxytocin inhibits the activity of acid‐sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons

British journal of pharmacology, 2014-06, Vol.171 (12), p.3065-3076

2014

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Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (12), p.E2504-E2513

2017

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Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

Journal of medicinal chemistry, 2017-10, Vol.60 (19), p.8192-8200

2017

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Endomorphins potentiate acid‐sensing ion channel currents and enhance the lactic acid‐mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia

The Journal of physiology, 2017-12, Vol.595 (23), p.7167-7183

2017

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Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2016-08, Vol.371 (1700), p.20150431

2016

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Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death

Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.E7469-E7477

2018

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Gating mechanisms of acid-sensing ion channels

Nature (London), 2018-03, Vol.555 (7696), p.397-401

2018

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Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

Nature Medicine, 2012-08, Vol.18 (8), p.1205-1207

2012

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Independent Contribution of Extracellular Proton Binding Sites to ASIC1a Activation

The Journal of biological chemistry, 2013-11, Vol.288 (48), p.34375-34383

2013

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ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury

Neuroscience, 2017-02, Vol.343, p.398-410

2017

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Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

Brain (London, England : 1878), 2013, Vol.136 (Pt 1), p.106-115

2013

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Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride

International journal of molecular sciences, 2020-11, Vol.21 (23), p.8921

2020

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NS383 Selectively Inhibits Acid‐Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats

CNS neuroscience & therapeutics, 2016-02, Vol.22 (2), p.135-145

2016

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Molecular basis of inhibition of acid sensing ion channel 1A by diminazene

PloS one, 2018-05, Vol.13 (5), p.e0196894

2018

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International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel

Photomodulation of the ASIC1a acidic pocket destabilizes the open state

ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating

The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity

Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss

Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation

Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

Acid-Sensing Ion Channels Structural Aspects, Pathophysiological Importance and Experimental Mutational Data Available Across Various Species to Target Human ASIC1

Genetic or Pharmacological Ablation of Acid-Sensing Ion Channel 1a (ASIC1a) Is Not Neuroprotective in a Mouse Model of Spinal Cord Injury

Oxytocin inhibits the activity of acid‐sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons

Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive

Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen

Endomorphins potentiate acid‐sensing ion channel currents and enhance the lactic acid‐mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia

Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy

Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death

Gating mechanisms of acid-sensing ion channels

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

Independent Contribution of Extracellular Proton Binding Sites to ASIC1a Activation

ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride

NS383 Selectively Inhibits Acid‐Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats

Molecular basis of inhibition of acid sensing ion channel 1A by diminazene

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