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N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxyl ic acid a novel scaffold for the design of uncompetitive I--glucosidase inhibitors

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (18), p.5811-5822

2013

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Acarbose improves health and lifespan in aging HET3 mice

Aging cell, 2019-04, Vol.18 (2), p.e12898-n/a

2019

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α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study

Journal of enzyme inhibition and medicinal chemistry, 2017-01, Vol.32 (1), p.1216-1228

2017

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Dietary Flavonoids and Acarbose Synergistically Inhibit α‑Glucosidase and Lower Postprandial Blood Glucose

Journal of agricultural and food chemistry, 2017-09, Vol.65 (38), p.8319-8330

2017

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Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

PloS one, 2021-12, Vol.16 (12), p.e0260853

2021

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The human microbiome encodes resistance to the antidiabetic drug acarbose

Nature (London), 2021-12, Vol.600 (7887), p.110-115

2021

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Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose

Bioorganic & medicinal chemistry letters, 2017-11, Vol.27 (22), p.5065-5070

2017

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Drug screening of α‐amylase inhibitors as candidates for treating diabetes

Journal of cellular and molecular medicine, 2023-08, Vol.27 (15), p.2249-2260

2023

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Studies on α-amylase inhibition by acarbose and quercetin using fluorescence, circular dichroism, docking, and dynamics simulations

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2024-06, Vol.314, p.124160, Article 124160

2024

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Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Aging cell, 2014-04, Vol.13 (2), p.273-282

2014

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Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges

European journal of medicinal chemistry, 2023-03, Vol.249, p.115119-115119, Article 115119

2023

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Comparative study of inhibition mechanisms of structurally different flavonoid compounds on α-glucosidase and synergistic effect with acarbose

Food chemistry, 2021-06, Vol.347, p.129056, Article 129056

2021

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Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

Nature communications, 2017-11, Vol.8 (1), p.1785-12, Article 1785

2017

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Reducing the intestinal side effects of acarbose by baicalein through the regulation of gut microbiota: An in vitro study

Food chemistry, 2022-11, Vol.394, p.133561-133561, Article 133561

2022

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High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota

Frontiers in endocrinology (Lausanne), 2022-02, Vol.12, p.806331-806331

2022

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Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

BMC microbiology, 2019-06, Vol.19 (1), p.130-130, Article 130

2019

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Taxifolin prevents postprandial hyperglycemia by regulating the activity of α‐amylase: Evidence from an in vivo and in silico studies

Journal of cellular biochemistry, 2019-01, Vol.120 (1), p.425-438

2019

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Reappraisal and perspectives of clinical drug-drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

Xenobiotica, 2018-01, Vol.48 (1), p.89-108

2018

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Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes

Bone (New York, N.Y.), 2023-05, Vol.170, p.116687-116687, Article 116687

2023

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Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus

Cochrane database of systematic reviews, 2018-12, Vol.12 (12), p.CD005061

2018

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Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial

The lancet. Diabetes & endocrinology, 2014, Vol.2 (1), p.46-55

2014

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International consensus on the diagnosis and management of dumping syndrome

Nature reviews. Endocrinology, 2020-08, Vol.16 (8), p.448

2020

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Effectiveness of dual combination therapy of acarbose plus metformin and acarbose plus myo-inositol in ameliorating the metabolic and endocrinologic complications of polycystic ovary syndrome – A randomized controlled trial

European journal of obstetrics & gynecology and reproductive biology, 2024-09, Vol.300, p.6-11

2024

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N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxyl ic acid a novel scaffold for the design of uncompetitive I--glucosidase inhibitors

Acarbose improves health and lifespan in aging HET3 mice

α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study

Dietary Flavonoids and Acarbose Synergistically Inhibit α‑Glucosidase and Lower Postprandial Blood Glucose

Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

The human microbiome encodes resistance to the antidiabetic drug acarbose

Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose

Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

Drug screening of α‐amylase inhibitors as candidates for treating diabetes

Studies on α-amylase inhibition by acarbose and quercetin using fluorescence, circular dichroism, docking, and dynamics simulations

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges

Comparative study of inhibition mechanisms of structurally different flavonoid compounds on α-glucosidase and synergistic effect with acarbose

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Reducing the intestinal side effects of acarbose by baicalein through the regulation of gut microbiota: An in vitro study

High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

Taxifolin prevents postprandial hyperglycemia by regulating the activity of α‐amylase: Evidence from an in vivo and in silico studies

Reappraisal and perspectives of clinical drug-drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus

Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes

Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus

Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial

International consensus on the diagnosis and management of dumping syndrome

Effectiveness of dual combination therapy of acarbose plus metformin and acarbose plus myo-inositol in ameliorating the metabolic and endocrinologic complications of polycystic ovary syndrome – A randomized controlled trial

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