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ApoE4: an emerging therapeutic target for Alzheimer's disease

BMC medicine, 2019-03, Vol.17 (1), p.64-17, Article 64

2019

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Effects of APOE4 on omega-3 brain metabolism across the lifespan

Trends in endocrinology and metabolism, 2024-08, Vol.35 (8), p.745-757

2024

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ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Cell reports (Cambridge), 2021-01, Vol.34 (1), p.108572-108572, Article 108572

2021

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Identifying those at risk for COVID-19 related suicide. Response to “Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?”

Neuroscience and biobehavioral reviews, 2022-09, Vol.140, p.104785-104785, Article 104785

2022

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The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

Alzheimer's & dementia, 2020-11, Vol.16 (11), p.1553-1560

2020

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Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

Immunity (Cambridge, Mass.), 2022-09, Vol.55 (9), p.1627-1644.e7

2022

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APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

Alzheimer's & dementia, 2014-11, Vol.10 (6), p.861-868

Michaelson, Daniel M

2014

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Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

Ageing research reviews, 2021-01, Vol.65, p.101208-101208, Article 101208

2021

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Protein intake and episodic memory: the moderating role of the apolipoprotein E ε4 status

Alzheimer's research & therapy, 2024-08, Vol.16 (1), p.181-13, Article 181

2024

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Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine

Pharmacology & therapeutics (Oxford), 2019-07, Vol.199, p.173-187

2019

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Manganese level and cognitive decline in older adults with the APOE e4 allele: a preliminary study

Psychiatry research, 2023-09, Vol.327, p.115403-115403, Article 115403

2023

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Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease

Journal of neuropsychology, 2024-03, Vol.18 (1), p.120-135

2024

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Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

Alzheimer's research & therapy, 2020-08, Vol.12 (1), p.1-10, Article 95

2020

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Hippocampal blood–brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia

Journal of cerebral blood flow and metabolism, 2021-06, Vol.41 (6), p.1351-1361

2021

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

Cell metabolism, 2017-11, Vol.26 (5), p.719-737.e6

2017

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Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

Journal of neuroinflammation, 2018-09, Vol.15 (1), p.276-276, Article 276

2018

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Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia

BioScience Trends, 2024, pp.2024.01092

2024

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Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

International journal of molecular sciences, 2021-06, Vol.22 (12), p.6355

2021

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Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's disease

Alzheimer's & dementia, 2020-01, Vol.16 (1), p.200-208

2020

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Exposure to coal dust exacerbates cognitive impairment by activating the IL6/ERK1/2/SP1 signaling pathway

The Science of the total environment, 2024-10, Vol.946, p.174202, Article 174202

2024

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Andrographolide Improves ApoE4-Mediated Blood-Brain Barrier Injury by Alleviating Inflammation

Molecular neurobiology, 2024-03

2024

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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Neuron (Cambridge, Mass.), 2023-01, Vol.111 (2), p.202-219.e7

2023

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Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease

Journal of Alzheimer's disease, 2015-09, Vol.48 (2), p.319

2015

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Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress

Environmental research, 2020-04, Vol.183, p.109137-109137, Article 109137

2020

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Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife

Journal of cerebral blood flow and metabolism, 2023-10, Vol.43 (10), p.1672-1684

2023

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ApoE4: an emerging therapeutic target for Alzheimer's disease

Effects of APOE4 on omega-3 brain metabolism across the lifespan

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Identifying those at risk for COVID-19 related suicide. Response to “Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?”

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria

Protein intake and episodic memory: the moderating role of the apolipoprotein E ε4 status

Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine

Manganese level and cognitive decline in older adults with the APOE e4 allele: a preliminary study

Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

Hippocampal blood–brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia

The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

Inflammation: the link between comorbidities, genetics, and Alzheimer's disease

Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's disease

Exposure to coal dust exacerbates cognitive impairment by activating the IL6/ERK1/2/SP1 signaling pathway

Andrographolide Improves ApoE4-Mediated Blood-Brain Barrier Injury by Alleviating Inflammation

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4

Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease

Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress

Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife

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