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New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B: JACC Focus Seminar 1/4

Journal of the American College of Cardiology, 2021-03, Vol.77 (12), p.1564-1575

2021

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Clinical Trial Design for Triglyceride-Rich Lipoprotein-Lowering Therapies

Journal of the American College of Cardiology, 2023-04, Vol.81 (16), p.1646-1658

2023

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Advancements in the Treatment of Homozygous Familial Hypercholesterolemia

Journal of Atherosclerosis and Thrombosis, 2022, pp.RV17065

2022

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New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B

Journal of the American College of Cardiology, 2021-03, Vol.77 (12), p.1564-1575

2021

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Downregulating ANGPTL3 by miR-144-3p promoted TGF-β1-induced renal interstitial fibrosis via activating PI3K/AKT signaling pathway

Heliyon, 2024-02, Vol.10 (3), p.e24204-e24204, Article e24204

2024

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A unified model for regulating lipoprotein lipase activity

Trends in endocrinology and metabolism, 2024-06, Vol.35 (6), p.490-504

2024

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Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

Cell metabolism, 2022-05, Vol.34 (5), p.667-680.e6

2022

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Transcriptomic therapy for dyslipidemias utilizing nucleic acids targeted at ANGPTL3

Future cardiology, 2022-02, Vol.18 (2), p.143-153

2022

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The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy

Frontiers in immunology, 2023-08, Vol.14, p.1228399-1228399

2023

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Angiopoietin-like protein 3 deficiency combined with valsartan administration protects better against podocyte damage in streptozotocin-induced diabetic nephropathy mice

International immunopharmacology, 2023-02, Vol.115, p.109715-109715, Article 109715

2023

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Marked plaque regression in homozygous familial hypercholesterolemia

Atherosclerosis, 2021-06, Vol.327, p.13-17

2021

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ANGPTL3: a novel biomarker and promising therapeutic target

Journal of drug targeting, 2019-09, Vol.27 (8), p.876-884

2019

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Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Journal of lipid research, 2021-01, Vol.62, p.100150-100150, Article 100150

Kersten, Sander

2021

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PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses

Metabolism, clinical and experimental, 2022-09, Vol.134, p.155265-155265, Article 155265

2022

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An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues

Progress in lipid research, 2022-01, Vol.85, p.101140-101140, Article 101140

2022

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Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Investigative ophthalmology & visual science, 2018-08, Vol.59 (10), p.4210-4217

2018

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Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

Circulation (New York, N.Y.), 2018-02, Vol.137 (9), p.975-977

2018

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Real-world experience of long-term efficacy and safety of evinacumab in patients with homozygous familial hypercholesterolemia treated and not treating with lipoprotein apheresis

Journal of clinical lipidology, 2024-05

2024

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Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade

Cell reports (Cambridge), 2022-09, Vol.40 (13), p.111422-111422, Article 111422

2022

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ANGPTL8: An Important Regulator in Metabolic Disorders

Frontiers in endocrinology (Lausanne), 2018-04, Vol.9, p.169-169

2018

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The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

Open biology, 2016-04, Vol.6 (4), p.150272-150272

Zhang, Ren

2016

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ANGPTL3 as therapeutic target

Current opinion in lipidology, 2021-12, Vol.32 (6), p.335-341

Kersten, Sander

2021

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Pemafibrate abrogates SLD in a rat experimental dietary model, inducing a shift in fecal bile acids and microbiota composition

Biomedicine & pharmacotherapy, 2024-08, Vol.177, p.117067, Article 117067

2024

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Complementary role of evinacumab in combination with lipoprotein apheresis in patients with homozygous familial hypercholesterolemia

Therapeutic apheresis and dialysis, 2022-12, Vol.26 (S1), p.12-17

2022

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New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B: JACC Focus Seminar 1/4

Clinical Trial Design for Triglyceride-Rich Lipoprotein-Lowering Therapies

Advancements in the Treatment of Homozygous Familial Hypercholesterolemia

New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B

Downregulating ANGPTL3 by miR-144-3p promoted TGF-β1-induced renal interstitial fibrosis via activating PI3K/AKT signaling pathway

A unified model for regulating lipoprotein lipase activity

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

Transcriptomic therapy for dyslipidemias utilizing nucleic acids targeted at ANGPTL3

The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy

Angiopoietin-like protein 3 deficiency combined with valsartan administration protects better against podocyte damage in streptozotocin-induced diabetic nephropathy mice

Marked plaque regression in homozygous familial hypercholesterolemia

ANGPTL3: a novel biomarker and promising therapeutic target

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses

An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3

Real-world experience of long-term efficacy and safety of evinacumab in patients with homozygous familial hypercholesterolemia treated and not treating with lipoprotein apheresis

Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade

ANGPTL8: An Important Regulator in Metabolic Disorders

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

ANGPTL3 as therapeutic target

Pemafibrate abrogates SLD in a rat experimental dietary model, inducing a shift in fecal bile acids and microbiota composition

Complementary role of evinacumab in combination with lipoprotein apheresis in patients with homozygous familial hypercholesterolemia

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