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The shedding protease ADAM17: Physiology and pathophysiology

Biochimica et biophysica acta. Molecular cell research, 2017-11, Vol.1864 (11), p.2059-2070

2017

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Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits

The EMBO journal, 2020-07, Vol.39 (13), p.e103695-n/a

2020

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ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19

Frontiers in immunology, 2020-10, Vol.11, p.576745

2020

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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Cell metabolism, 2020-02, Vol.31 (2), p.406-421.e7

2020

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Phosphatidylserine exposure is required for ADAM17 sheddase function

Nature communications, 2016-05, Vol.7 (1), p.11523-11523, Article 11523

2016

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Strategies to Target ADAM17 in Disease: From its Discovery to the iRhom Revolution

Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.944

2021

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Lysophosphatidic acid induces tumor necrosis factor‐alpha to regulate a pro‐inflammatory cytokine network in ovarian cancer

The FASEB journal, 2020-10, Vol.34 (10), p.13935-13948

2020

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ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer

Biochimica et biophysica acta. Molecular cell research, 2022-01, Vol.1869 (1), p.119141, Article 119141

2022

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Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17

The Journal of biological chemistry, 2024-07, Vol.300 (7), p.107480, Article 107480

2024

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The metalloprotease ADAM17 in inflammation and cancer

Pathology, research and practice, 2019-06, Vol.215 (6), p.152410-152410, Article 152410

2019

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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

EMBO molecular medicine, 2017-10, Vol.9 (10), p.1356-1365

2017

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Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19

Viruses, 2020-12, Vol.13 (1), p.29

2020

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ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

EMBO molecular medicine, 2019-04, Vol.11 (4), p.n/a

2019

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iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Journal of cell science, 2022-09, Vol.135 (17)

2022

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Blockade of the protease ADAM17 ameliorates experimental pancreatitis

Proceedings of the National Academy of Sciences - PNAS, 2022-10, Vol.119 (42), p.e2213744119

2022

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The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17

The FASEB journal, 2022-03, Vol.36 (3), p.e22234-n/a

2022

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ADAM proteases: Emerging role and targeting of the non-catalytic domains

Cancer letters, 2019-12, Vol.467, p.50-57

2019

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Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release

The FEBS journal, 2024-09, Vol.291 (17), p.3924-3937

2024

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ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

Viruses, 2020-04, Vol.12 (5), p.491

2020

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Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes

Biochimica et biophysica acta, 2016-11, Vol.1863 (11), p.2795-2808

2016

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Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

The FASEB journal, 2020-04, Vol.34 (4), p.4956-4969

2020

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Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

Platelets (Edinburgh), 2017-05, Vol.28 (4), p.333-341

2017

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iNOS promotes CD24⁺CD133⁺ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (43), p.E10127-E10136

2018

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The plasma membrane: Penultimate regulator of ADAM sheddase function

Biochimica et biophysica acta. Molecular cell research, 2017-11, Vol.1864 (11), p.2082-2087

2017

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Alpha‐1‐antitrypsin: A possible host protective factor against Covid‐19

Reviews in medical virology, 2021-03, Vol.31 (2), p.e2157-n/a

2021

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The shedding protease ADAM17: Physiology and pathophysiology

Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Phosphatidylserine exposure is required for ADAM17 sheddase function

Strategies to Target ADAM17 in Disease: From its Discovery to the iRhom Revolution

Lysophosphatidic acid induces tumor necrosis factor‐alpha to regulate a pro‐inflammatory cytokine network in ovarian cancer

ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17

The metalloprotease ADAM17 in inflammation and cancer

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Blockade of the protease ADAM17 ameliorates experimental pancreatitis

The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17

ADAM proteases: Emerging role and targeting of the non-catalytic domains

Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release

ACE2: The key Molecule for Understanding the Pathophysiology of Severe and Critical Conditions of COVID-19: Demon or Angel?

Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes

Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

iNOS promotes CD24⁺CD133⁺ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

The plasma membrane: Penultimate regulator of ADAM sheddase function

Alpha‐1‐antitrypsin: A possible host protective factor against Covid‐19

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