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A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction

Trends in pharmacological sciences (Regular ed.), 2018-12, Vol.39 (12), p.1008-1020

2018

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Adenosine A2A Receptor as a Drug Discovery Target

Journal of medicinal chemistry, 2014-05, Vol.57 (9), p.3623-3650

2014

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State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

Structure (London), 2019-02, Vol.27 (2), p.392-403.e3

2019

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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Brain (London, England : 1878), 2019-11, Vol.142 (11), p.3636-3654

2019

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Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment

Cancer research (Chicago, Ill.), 2014-12, Vol.74 (24), p.7250-7259

2014

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Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6470-6479

2016

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Blockade of A₂A receptors potently suppresses the metastasis of CD73⁺ tumors

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.14711-14716

2013

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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

Bioscience reports, 2015-04, Vol.35 (2)

2015

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Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

Structure (London), 2012-06, Vol.20 (6), p.967-976

2012

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Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine

Structure (London), 2011-09, Vol.19 (9), p.1283

2011

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Adenosine A2A receptors modulate α-Synuclein aggregation and toxicity

Cerebral cortex (New York, N.Y. 1991), 2017-01, Vol.27 (1), p.718-730

2017

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Membrane mimetic-dependence of GPCR energy landscapes

Structure (London), 2024-05, Vol.32 (5), p.523-535.e5

2024

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Metabotropic glutamate type 5, dopamine D₂ and adenosine A₂a receptors form higher-order oligomers in living cells

Journal of neurochemistry, 2009-06, Vol.109 (5), p.1497-1507

2009

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Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A2A receptor (A2A AR) antagonist

European journal of medicinal chemistry, 2021-01, Vol.210, p.113040, Article 113040

2021

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Blockade of adenosine A2A receptor enhances CD8 + T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Molecular cancer, 2017-06, Vol.16 (1), p.99-99, Article 99

2017

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Effects of the adenosine A2A receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of Parkinson's disease

Neuropharmacology, 2024-04, Vol.247, p.109862-109862, Article 109862

2024

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Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition

Structure (London), 2023-07, Vol.31 (7), p.836-847.e6

2023

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Convergence of adenosine and GABA signaling for synapse stabilization during development

Science (American Association for the Advancement of Science), 2021-11, Vol.374 (6568), p.eabk2055

2021

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G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

Nature (London), 2012-01, Vol.482 (7384), p.237-240

2012

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Adenosine A2A receptor activation reduces chondrocyte senescence

The FASEB journal, 2023-04, Vol.37 (4), p.e22838-n/a

2023

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Neuroprotection by caffeine in the MPTP model of Parkinson’s disease and its dependence on adenosine A2A receptors

Neuroscience, 2016-05, Vol.322, p.129-137

2016

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Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1

Biochimica et biophysica acta, 2016-07, Vol.1863 (7), p.1461-1471

2016

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Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors

Cell reports (Cambridge), 2021-08, Vol.36 (7), p.109558-109558, Article 109558

2021

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Knockdown of adenosine A2A receptors in hippocampal neurons prevents post-TBI fear memory retrieval

Experimental neurology, 2023-06, Vol.364, p.114378-114378, Article 114378

2023

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Solvent accessibility of a GPCR transmembrane domain probed by in‐membrane chemical modification (IMCM)

FEBS letters, 2023-06, Vol.597 (11), p.1541-1549

2023

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A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction

Adenosine A2A Receptor as a Drug Discovery Target

State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

Blockade of A₂A receptors potently suppresses the metastasis of CD73⁺ tumors

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine

Adenosine A2A receptors modulate α-Synuclein aggregation and toxicity

Membrane mimetic-dependence of GPCR energy landscapes

Metabotropic glutamate type 5, dopamine D₂ and adenosine A₂a receptors form higher-order oligomers in living cells

Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A2A receptor (A2A AR) antagonist

Blockade of adenosine A2A receptor enhances CD8 + T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

Effects of the adenosine A2A receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of Parkinson's disease

Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition

Convergence of adenosine and GABA signaling for synapse stabilization during development

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

Adenosine A2A receptor activation reduces chondrocyte senescence

Neuroprotection by caffeine in the MPTP model of Parkinson’s disease and its dependence on adenosine A2A receptors

Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1

Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors

Knockdown of adenosine A2A receptors in hippocampal neurons prevents post-TBI fear memory retrieval

Solvent accessibility of a GPCR transmembrane domain probed by in‐membrane chemical modification (IMCM)

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