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First results of triple‐modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with Stage IIB, III, and IVA cervical carcinoma

Cancer, 2005-08, Vol.104 (4), p.763-770

2005

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Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity

Molecular cancer therapeutics, 2002-04, Vol.1 (6), p.371

2002

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Thymidylate Synthase Level as the Main Predictive Parameter for Sensitivity to 5-Fluorouracil, but not for Folate-based Thymidylate Synthase Inhibitors, in 13 Nonselected Colon Cancer Cell Lines

Clinical cancer research, 1999-03, Vol.5 (3), p.643-654

1999

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High-Dose 5-Fluorouracil with Uridine-Diphosphoglucose Rescue Increases Thymidylate Synthase Inhibition but Not 5-Fluorouracil Incorporation into RNA in Murine Tumors

Oncology, 2002-01, Vol.62 (4), p.363-370

2002

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Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors

Cancer research (Baltimore), 2001-05, Vol.61 (9), p.3675-3681

2001

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The multilayered postconfluent cell culture as a model for drug screening

Critical reviews in oncology/hematology, 2000-11, Vol.36 (2), p.141-157

2000

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Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2′-2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000

Biochemical pharmacology, 2004-08, Vol.68 (4), p.601-609

2004

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Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures

Anti-cancer drugs, 1999-06, Vol.10 (5), p.445-452

1999

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Effects of antifolates on the binding of 5-fluoro-2′-deoxyuridine monophosphate to thymidylate synthase

Biochemical pharmacology, 2002-08, Vol.64 (4), p.669-675

2002

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Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors

Cancer research (Chicago, Ill.), 1992-09, Vol.52 (18), p.4922-4928

1992

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5-Ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil

Journal of cancer research and clinical oncology, 1999-12, Vol.125 (12), p.675-684

1999

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Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice

European journal of cancer (1990), 1992, Vol.28 (12), p.2017-2024

1992

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Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression

Biochemical pharmacology, 1997-06, Vol.53 (12), p.1855-1866

1997

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The role of deoxycytidine kinase in gemcitabine cytotoxicity

Advances in experimental medicine and biology, 2000, Vol.486, p.287

2000

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Pretreatment Deoxycytidine Kinase Levels Predict in Vivo Gemcitabine Sensitivity 1 Supported by Eli Lilly & Co, International and The Netherlands.1

Molecular cancer therapeutics, 2002-04, Vol.1 (6), p.371

2002

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Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model

Clinical cancer research, 1996-08, Vol.2 (8), p.1327-1333

1996

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Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines

Oncology research, 1999, Vol.11 (8), p.383

1999

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The multilayered postconfluent cell culture as a model for drug screening: Spheroids

Critical reviews in oncology/hematology, 2000, Vol.36 (2-3), p.141-157

2000

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Addition of leucovorin in modulation of 5‐fluorouracil with methotrexate: Potentiating or reversing effect?

International journal of cancer, 1995-05, Vol.61 (5), p.672-678

1995

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Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas

Cancer chemotherapy and pharmacology, 1996, Vol.39 (1-2), p.79-89

1996

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5-Fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

Journal of cancer research and clinical oncology, 1997, Vol.123 (11-12), p.595-601

1997

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Erratum: J Cancer Res Clin Oncol (1997) 123: 595—601

Journal of cancer research and clinical oncology, 1998-03, Vol.124 (2), p.130-130

1998

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The combination 5-fluorouracil/levamisole induces enhanced rat kupffer cell-mediated cytotoxicity in vitro against the syngeneic colon adenocarcinoma cell line CC531

Journal of surgical oncology, 1995-11, Vol.60 (3), p.180-184

1995

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Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'- monophosphate to thymidylate synthase

Biochemical pharmacology, 1993-03, Vol.45 (5), p.1177-1179

1993

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Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase

Seminars in oncology, 1992-04, Vol.19 (2), p.16-25

1992

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Colonic Neoplasms - Drug Therapy
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Fluorodeoxyuridylate - Metabolism
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First results of triple‐modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with Stage IIB, III, and IVA cervical carcinoma

Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity

Thymidylate Synthase Level as the Main Predictive Parameter for Sensitivity to 5-Fluorouracil, but not for Folate-based Thymidylate Synthase Inhibitors, in 13 Nonselected Colon Cancer Cell Lines

High-Dose 5-Fluorouracil with Uridine-Diphosphoglucose Rescue Increases Thymidylate Synthase Inhibition but Not 5-Fluorouracil Incorporation into RNA in Murine Tumors

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors

The multilayered postconfluent cell culture as a model for drug screening

Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2′-2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000

Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures

Effects of antifolates on the binding of 5-fluoro-2′-deoxyuridine monophosphate to thymidylate synthase

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors

5-Ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil

Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression

The role of deoxycytidine kinase in gemcitabine cytotoxicity

Pretreatment Deoxycytidine Kinase Levels Predict in Vivo Gemcitabine Sensitivity 1 Supported by Eli Lilly & Co, International and The Netherlands.1

Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model

Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines

The multilayered postconfluent cell culture as a model for drug screening: Spheroids

Addition of leucovorin in modulation of 5‐fluorouracil with methotrexate: Potentiating or reversing effect?

Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas

5-Fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

Erratum: J Cancer Res Clin Oncol (1997) 123: 595—601

The combination 5-fluorouracil/levamisole induces enhanced rat kupffer cell-mediated cytotoxicity in vitro against the syngeneic colon adenocarcinoma cell line CC531

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'- monophosphate to thymidylate synthase

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase

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