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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Clinical pharmacology and therapeutics, 2013-06, Vol.93 (6), p.502-514

2013

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A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

CPT: pharmacometrics and systems pharmacology, 2015-06, Vol.4 (6), p.324-337

2015

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A Six‐Stage Workflow for Robust Application of Systems Pharmacology

CPT: pharmacometrics and systems pharmacology, 2016-05, Vol.5 (5), p.235-249

2016

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Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014)

CPT: pharmacometrics and systems pharmacology, 2017-07, Vol.6 (7), p.418-429

2017

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Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

CPT: pharmacometrics and systems pharmacology, 2017-08, Vol.6 (8), p.496-498

2017

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Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models

CPT: Pharmacometrics & Systems Pharmacology, 2014-12, Vol.3 (12), p.1-2

Graaf, PH

2014

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Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

CPT: pharmacometrics and systems pharmacology, 2016-07, Vol.5 (7), p.339-351

2016

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Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis

CPT: pharmacometrics and systems pharmacology, 2012-10, Vol.1 (10), p.1-9

2012

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Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic‐Pharmacodynamic Behavior: An Example Using 5‐Lipoxygenase Inhibitors

CPT: pharmacometrics and systems pharmacology, 2013-09, Vol.2 (9), p.1-9

2013

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A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

CPT: pharmacometrics and systems pharmacology, 2014-01, Vol.3 (1), p.1-7

2014

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Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology

CPT: pharmacometrics and systems pharmacology, 2015-08, Vol.4 (8), p.443-444

2015

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Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

Clinical pharmacology and therapeutics, 2013-05, Vol.93 (5), p.379-381

2013

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Systems Approaches Evolve Clinical Pharmacology

CPT: pharmacometrics and systems pharmacology, 2013-08, Vol.2 (8), p.1-2

2013

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CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

CPT: pharmacometrics and systems pharmacology, 2014-03, Vol.3 (3), p.1-2

2014

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What Pharmacometricians (Should) Do

CPT: pharmacometrics and systems pharmacology, 2013-05, Vol.2 (5), p.1-1

Graaf, PH

2013

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Regulatory Modeling and Simulation Moves Into the Next Gear in Europe

CPT: pharmacometrics and systems pharmacology, 2013-02, Vol.2 (2), p.1-1

Graaf, PH

2013

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Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

CPT: pharmacometrics and systems pharmacology, 2013-12, Vol.2 (12), p.1-3

2013

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Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors

CPT: pharmacometrics and systems pharmacology, 2014-12, Vol.3 (12), p.1-8

2014

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Model‐Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Clinical pharmacology and therapeutics, 2013-06, Vol.93 (6), p.502-514

2013

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Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats

The Journal of pharmacology and experimental therapeutics, 2002-09, Vol.302 (3), p.1158-1167

2002

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The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S83-S89

2017

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UK‐414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve‐stimulated increases in female genital blood flow in the anaesthetized rabbit

British journal of pharmacology, 2010-05, Vol.160 (1), p.51-59

2010

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Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis

British journal of pharmacology, 2015-09, Vol.172 (17), p.4364-4379

2015

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Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.431-440

2017

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Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats

The Journal of pharmacology and experimental therapeutics, 2003-11, Vol.307 (2), p.765-775

2003

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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

A Tutorial on Target‐Mediated Drug Disposition (TMDD) Models

A Six‐Stage Workflow for Robust Application of Systems Pharmacology

Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014)

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis With Nonlinear Mixed Effects Models

Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study

Integrated Pharmacometrics and Systems Pharmacology Model‐Based Analyses to Guide GnRH Receptor Modulator Development for Management of Endometriosis

Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic‐Pharmacodynamic Behavior: An Example Using 5‐Lipoxygenase Inhibitors

A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain

Database: A New Article Type in CPT: Pharmacometrics & Systems Pharmacology

Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

Systems Approaches Evolve Clinical Pharmacology

CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

What Pharmacometricians (Should) Do

Regulatory Modeling and Simulation Moves Into the Next Gear in Europe

Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors

Model‐Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats

The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

UK‐414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve‐stimulated increases in female genital blood flow in the anaesthetized rabbit

Inter‐study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta‐analysis

Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats

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