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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Frontiers in immunology, 2019-01, Vol.9, p.3037-3037

2019

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The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Trends in pharmacological sciences (Regular ed.), 2018-04, Vol.39 (4), p.424-436

2018

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Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

Frontiers in immunology, 2018-04, Vol.9, p.889-889

2018

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Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity

Cardiovascular research, 2024-03, Vol.120 (3), p.286-300

2024

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Heavy-chain antibody targeting of CD38 NAD + hydrolase ectoenzyme to prevent fibrosis in multiple organs

Scientific reports, 2023-12, Vol.13 (1), p.22085-10, Article 22085

2023

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Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release

Journal for immunotherapy of cancer, 2021-06, Vol.9 (6), p.e002488

2021

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TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

mAbs, 2022-07, Vol.14 (1), p.2095949-2095949

2022

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TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL

mAbs, 2021-01, Vol.13 (1), p.1890411

2021

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Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

mAbs, 2020-01, Vol.12 (1), p.1846900-1846900

2020

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Abstract 5620: Multispecific antibodies targeting CD38 and PD-L1 show potent tumor cytotoxicity

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5620-5620

Schooten, Wim van

2018

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Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus

Gene, 2004-04, Vol.330, p.49-59

2004

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A Mycobacterium leprae--Specific Human T Cell Epitope Cross-Reactive with an HLA-DR2 Peptide

Science (American Association for the Advancement of Science), 1988-10, Vol.242 (4876), p.259-261

1988

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Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias

Journal of molecular and cellular cardiology, 2022-05, Vol.166, p.11-22

2022

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Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

mAbs, 2019-05, Vol.11 (4), p.639-652

2019

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The Pharmacology of CD38/NADase: An emerging target for cancer and aging diseases

Trends in pharmacological sciences (Regular ed.), 2018-02, Vol.39 (4), p.424-436

2018

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TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Blood, 2019-11, Vol.134 (Supplement_1), p.4070-4070

2019

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Evaluation of monovalent versus biparatopic CD3xPSMA bispecific antibodies for t-cell mediated killing of prostate tumor cells with minimal cytokine release

Journal of clinical oncology, 2019-05, Vol.37 (15_suppl), p.e16519-e16519

2019

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In Vivo Persistence of Donor Cells following Adoptive Transfer of Allogeneic Dendritic Cells in HIV-Infected Patients

Cell transplantation, 2000-05, Vol.9 (3), p.307-317

2000

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A novel CD3xPSMA bispecific antibody for efficient T cell mediated killing of prostate tumor cells with minimal cytokine release

Journal of clinical oncology, 2019-03, Vol.37 (7_suppl), p.324-324

2019

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Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.8017-8017

2017

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Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.8034-8034

2018

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Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1554-1554

2019

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Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma

Journal of clinical oncology, 2018-02, Vol.36 (5_suppl), p.60-60

2018

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A novel T-cell bispecific antibody platform for efficient T-cell mediated killing of tumor cells with minimal cytokine release

Journal of clinical oncology, 2018-02, Vol.36 (5_suppl), p.209-209

2018

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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity

Heavy-chain antibody targeting of CD38 NAD + hydrolase ectoenzyme to prevent fibrosis in multiple organs

Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL

Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

Abstract 5620: Multispecific antibodies targeting CD38 and PD-L1 show potent tumor cytotoxicity

Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus

A Mycobacterium leprae--Specific Human T Cell Epitope Cross-Reactive with an HLA-DR2 Peptide

Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

The Pharmacology of CD38/NADase: An emerging target for cancer and aging diseases

TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion

Evaluation of monovalent versus biparatopic CD3xPSMA bispecific antibodies for t-cell mediated killing of prostate tumor cells with minimal cytokine release

In Vivo Persistence of Donor Cells following Adoptive Transfer of Allogeneic Dendritic Cells in HIV-Infected Patients

A novel CD3xPSMA bispecific antibody for efficient T cell mediated killing of prostate tumor cells with minimal cytokine release

Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma

Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma

Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies

Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma

A novel T-cell bispecific antibody platform for efficient T-cell mediated killing of tumor cells with minimal cytokine release

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