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TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy

Current pharmaceutical biotechnology, 2011-12, Vol.12 (12), p.2108

2011

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Regulation and biological activities of the autotaxin–LPA axis

Progress in lipid research, 2007-03, Vol.46 (2), p.145-160

2007

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Vascular endothelial growth factor B controls endothelial fatty acid uptake

Nature (London), 2010-04, Vol.464 (7290), p.917-921

2010

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NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

Developmental cell, 2014-03, Vol.28 (6), p.633-646

2014

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Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Journal of lipid research, 2011-06, Vol.52 (6), p.1247-1255

2011

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Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (16), p.7257-7262

2010

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Structural basis of substrate discrimination and integrin binding by autotaxin

Nature structural & molecular biology, 2011-02, Vol.18 (2), p.198

2011

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Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

Molecular and Cellular Biology, 2006-07, Vol.26 (13), p.5015-5022

2006

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Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

Blood, 2008-11, Vol.112 (9), p.3638-3649

2008

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GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2

Angiogenesis (London), 2013-10, Vol.16 (4), p.939-952

2013

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Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

The Journal of biological chemistry, 2009-03, Vol.284 (11), p.7385-7394

2009

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Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin

Journal of medicinal chemistry, 2010-07, Vol.53 (13), p.4958-4967

2010

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A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression

Molecular cancer research, 2010-08, Vol.8 (8), p.1063-1073

2010

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Fluorogenic Phospholipid Substrate to Detect Lysophospholipase D/Autotaxin Activity

Organic letters, 2006-05, Vol.8 (10), p.2023-2026

2006

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Anticancer activity of FTY720: Phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D

Cancer letters, 2008-08, Vol.266 (2), p.203-208

2008

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Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts

Experimental cell research, 2013-05, Vol.319 (9), p.1264-1270

2013

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Spider and Bacterial Sphingomyelinases D Target Cellular Lysophosphatidic Acid Receptors by Hydrolyzing Lysophosphatidylcholine

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.10833-10836

2004

Volltextzugriff (PDF)

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

The Journal of biological chemistry, 2012-05, Vol.287 (22), p.18551-18561

2012

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Suppression of the p53-Dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling

Molecular cancer research, 2008-09, Vol.6 (9), p.1452-1460

2008

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Autotaxin in embryonic development

Biochimica et biophysica acta, 2013-01, Vol.1831 (1), p.13-19

2013

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The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

The Journal of biological chemistry, 2013-01, Vol.288 (1), p.510-519

2013

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ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis

PloS one, 2014-01, Vol.9 (1), p.e86273-e86273

2014

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Synthesis, Structure−Activity Relationships, and Biological Evaluation of Fatty Alcohol Phosphates as Lysophosphatidic Acid Receptor Ligands, Activators of PPARγ, and Inhibitors of Autotaxin

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4919-4930

2005

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Upregulation of Cytokine Expression in Fibroblasts Exposed to Loxosceles Sphingomyelinase D: What is the Trigger?

Journal of investigative dermatology, 2007-05, Vol.127 (5), p.1266-1267

2007

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Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein

Acta crystallographica. Section F, Structural biology and crystallization communications, 2010-09, Vol.66 (9), p.1130-1135

2010

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TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy

Regulation and biological activities of the autotaxin–LPA axis

Vascular endothelial growth factor B controls endothelial fatty acid uptake

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Structural basis of substrate discrimination and integrin binding by autotaxin

Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2

Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis

Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin

A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression

Fluorogenic Phospholipid Substrate to Detect Lysophospholipase D/Autotaxin Activity

Anticancer activity of FTY720: Phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D

Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts

Spider and Bacterial Sphingomyelinases D Target Cellular Lysophosphatidic Acid Receptors by Hydrolyzing Lysophosphatidylcholine

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

Suppression of the p53-Dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling

Autotaxin in embryonic development

The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

ENDOGLIN is dispensable for vasculogenesis, but required for vascular endothelial growth factor-induced angiogenesis

Synthesis, Structure−Activity Relationships, and Biological Evaluation of Fatty Alcohol Phosphates as Lysophosphatidic Acid Receptor Ligands, Activators of PPARγ, and Inhibitors of Autotaxin

Upregulation of Cytokine Expression in Fibroblasts Exposed to Loxosceles Sphingomyelinase D: What is the Trigger?

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein

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