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Anticancer mechanisms and clinical application of alkylphospholipids

Biochimica et biophysica acta, 2013-03, Vol.1831 (3), p.663-674

2013

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Ceramide: second messenger or modulator of membrane structure and dynamics?

Biochemical journal, 2003-01, Vol.369 (Pt 2), p.199-211

2003

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Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

Biochemical journal, 2007-01, Vol.401 (2), p.541-549

2007

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A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

Molecular cancer therapeutics, 2007-08, Vol.6 (8), p.2337-2345

2007

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Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects

Current pharmaceutical design, 2008-07, Vol.14 (21), p.2061

2008

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Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

The Journal of biological chemistry, 2002-10, Vol.277 (42), p.39541-39547

2002

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Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook

Anti-cancer agents in medicinal chemistry, 2014-05, Vol.14 (4), p.618

2014

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Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

The Journal of biological chemistry, 2004-06, Vol.279 (25), p.26167-26175

2004

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AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

Radiation oncology (London, England), 2009-10, Vol.4 (1), p.47-47, Article 47

2009

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Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

Clinical cancer research, 2006-03, Vol.12 (5), p.1615-1622

2006

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Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

Biochemical journal, 2003-09, Vol.374 (Pt 3), p.747-753

2003

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Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.704

2005

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Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Biochemical journal, 2009-12, Vol.425 (1), p.225-236

2009

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Properties and functions of diacylglycerol kinases

Cellular Signalling, 2000-10, Vol.12 (9), p.595-605

2000

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Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors

The FASEB journal, 2011, Vol.25 (1), p.280-289

2011

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SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling

The Journal of immunology (1950), 2011-12, Vol.187 (11), p.5941-5951

2011

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Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

Cancer treatment reviews, 2007-04, Vol.33 (2), p.191-202

2007

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Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance

Scientific reports, 2013-06, Vol.3 (1), p.1949, Article 1949

2013

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Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor

The international journal of biochemistry & cell biology, 2012-11, Vol.44 (11), p.1791-1799

2012

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The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

Radiotherapy and oncology, 1998-06, Vol.47 (3), p.225-232

1998

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Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase–Akt/PKB survival pathway

Anti-cancer drugs, 2003-02, Vol.14 (2), p.167-173

2003

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Translocation of Diacylglycerol Kinase θ from Cytosol to Plasma Membrane in Response to Activation of G Protein-coupled Receptors and Protein Kinase C

The Journal of biological chemistry, 2005-03, Vol.280 (11), p.9870-9878

2005

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Improving Intracellular Doxorubicin Delivery Through Nanoliposomes Equipped with Selective Tumor Cell Membrane Permeabilizing Short-Chain Sphingolipids

Pharmaceutical research, 2013-07, Vol.30 (7), p.1883-1895

2013

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Activation of α-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

Blood, 2005-09, Vol.106 (6), p.2175-2182

2005

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Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

Cancer research (Chicago, Ill.), 1999-05, Vol.59 (10), p.2457-2463

1999

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Anticancer mechanisms and clinical application of alkylphospholipids

Ceramide: second messenger or modulator of membrane structure and dynamics?

Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects

Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

Properties and functions of diacylglycerol kinases

Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors

SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase–Akt/PKB survival pathway

Translocation of Diacylglycerol Kinase θ from Cytosol to Plasma Membrane in Response to Activation of G Protein-coupled Receptors and Protein Kinase C

Improving Intracellular Doxorubicin Delivery Through Nanoliposomes Equipped with Selective Tumor Cell Membrane Permeabilizing Short-Chain Sphingolipids

Activation of α-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

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