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Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases : implications for chemotherapy with 5-fluoropyrimidines

Cancer research (Chicago, Ill.), 1993-08, Vol.53 (16), p.3687-3693

1993

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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii

Antimicrobial Agents and Chemotherapy, 1999-10, Vol.43 (10), p.2437-2443

1999

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Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii

Biochemical pharmacology, 1995-11, Vol.50 (10), p.1685-1693

1995

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Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from toxoplasma gondii

Biochemical pharmacology, 1999-11, Vol.58 (9), p.1457-1466

1999

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Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1477-1480

1999

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Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Cancer chemotherapy and pharmacology, 2001-08, Vol.48 (2), p.145-150

2001

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Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii

Biochemical pharmacology, 1995-05, Vol.49 (10), p.1501-1512

1995

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5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase

Biochemical pharmacology, 2000-09, Vol.60 (6), p.851-856

2000

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Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- O-acetyluridine, a prodrug of uridine

Biochemical pharmacology, 2000-08, Vol.60 (3), p.427-431

2000

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The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression

The Journal of biological chemistry, 1999-12, Vol.274 (49), p.35255-35261

1999

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Enzymes of uracil catabolism in normal and neoplastic human tissues

Cancer research (Chicago, Ill.), 1985-11, Vol.45 (11), p.5405-5412

1985

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Potential chemotherapeutic targets in the purine metabolism of parasites

Pharmacology & therapeutics (Oxford), 2003-09, Vol.99 (3), p.283-309

el Kouni, Mahmoud H

2003

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Antiviral Activity and Intracellular Metabolism of Bis(tButylSATE) Phosphotriester of β-L-2′,3'Dideoxyadenosine, a Potent Inhibitor of HIV and HBV Replication

Antiviral chemistry & chemotherapy, 2001-04, Vol.12 (2), p.99-108

2001

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Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis

Antimicrobial Agents and Chemotherapy, 1989-06, Vol.33 (6), p.824-827

1989

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Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase : relevance to chemotherapy

Cancer chemotherapy and pharmacology, 2000, Vol.45 (5), p.351-361

2000

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Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii

Biochemical pharmacology, 1996-06, Vol.51 (12), p.1687-1700

1996

Volltextzugriff (PDF)

Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2', 3', 5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy

Cancer chemotherapy and pharmacology, 2000, Vol.46 (3), p.235-240

2000

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Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside

Cancer research (Chicago, Ill.), 1995-03, Vol.55 (5), p.1092-1098

1995

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Uridine phosphorylase from Schistosoma mansoni

The Journal of biological chemistry, 1988-05, Vol.263 (13), p.6081-6086

1988

Volltextzugriff (PDF)

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Biochemical pharmacology, 1995-01, Vol.50 (10), p.1685-1693

1995

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Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus

Molecular and biochemical parasitology, 1999-09, Vol.103 (1), p.1-14

1999

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Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate

Proceedings of the National Academy of Sciences - PNAS, 1983-11, Vol.80 (21), p.6667-6670

1983

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Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4250-4254

1993

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Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy

Cancer chemotherapy and pharmacology, 2001-11, Vol.48 (5), p.389-397

2001

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Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases : implications for chemotherapy with 5-fluoropyrimidines

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii

Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from toxoplasma gondii

Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition

Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii

5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase

Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- O-acetyluridine, a prodrug of uridine

The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression

Enzymes of uracil catabolism in normal and neoplastic human tissues

Potential chemotherapeutic targets in the purine metabolism of parasites

Antiviral Activity and Intracellular Metabolism of Bis(tButylSATE) Phosphotriester of β-L-2′,3'Dideoxyadenosine, a Potent Inhibitor of HIV and HBV Replication

Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis

Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase : relevance to chemotherapy

Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii

Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2', 3', 5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy

Enhancement of 5-fluoro-2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-(benzyloxybenzyl)barbituric acid acyclonucleoside

Uridine phosphorylase from Schistosoma mansoni

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus

Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate

Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase

Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy

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