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Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology

Angewandte Chemie International Edition, 2021-04, Vol.60 (15), p.8050-8071

International ed. in English, 2021

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Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Nature communications, 2022-01, Vol.13 (1), p.260-260, Article 260

2022

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Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

Angewandte Chemie International Edition, 2020-07, Vol.59 (28), p.11273-11277

International ed. in English, 2020

Volltextzugriff (PDF)

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Nature protocols, 2021-03, Vol.16 (3), p.1740-1760

2021

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Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

Biochemical journal, 2015-07, Vol.469 (2), p.243-253

2015

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Cyclotides: From Structure to Function

Chemical reviews, 2019-12, Vol.119 (24), p.12375-12421

2019

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Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7287-7292

2016

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Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

Journal of virology, 2017-08, Vol.91 (16)

2017

Volltextzugriff (PDF)

Characterising the Subsite Specificity of Urokinase‐Type Plasminogen Activator and Tissue‐Type Plasminogen Activator using a Sequence‐Defined Peptide Aldehyde Library

Chembiochem : a European journal of chemical biology, 2019-01, Vol.20 (1), p.46-50

2019

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Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

PloS one, 2019, Vol.14 (1), p.e0210842-e0210842

2019

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Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

PloS one, 2011-04, Vol.6 (4), p.e19302-e19302

2011

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Cyclotides as Tools in Chemical Biology

Accounts of chemical research, 2017-07, Vol.50 (7), p.1557-1565

2017

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Proteases and proteomics: Cutting to the core of human skin pathologies

Proteomics. Clinical applications, 2014-06, Vol.8 (5-6), p.389-402

2014

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Enzymatic C‐to‐C Protein Ligation

Angewandte Chemie (International ed.), 2022-03, Vol.61 (11), p.e202116672-n/a

International ed. in English, 2022

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Enzymatic C‑Terminal Protein Engineering with Amines

Journal of the American Chemical Society, 2021-11, Vol.143 (46), p.19498-19504

2021

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Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

Biological chemistry, 2012-05, Vol.393 (5), p.331-341

2012

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Nucleation of a key beta-turn promotes cyclotide oxidative folding

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107125-107125, Article 107125

2024

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Proteases: common culprits in human skin disorders

Trends in molecular medicine, 2014-03, Vol.20 (3), p.166-178

2014

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Cystine Knot Peptides with Tuneable Activity and Mechanism

Angewandte Chemie International Edition, 2022-05, Vol.61 (19), p.e202200951-n/a

International ed. in English, 2022

Volltextzugriff (PDF)

An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β‑Factor XIIa in a Cyclotide Scaffold

Journal of the American Chemical Society, 2021-11, Vol.143 (44), p.18481-18489

2021

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Binding Loop Substitutions in the Cyclic Peptide SFTI‑1 Generate Potent and Selective Chymase Inhibitors

Journal of medicinal chemistry, 2020-01, Vol.63 (2), p.816-826

2020

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Tertiary amide bond formation by an engineered asparaginyl ligase

Chemical science (Cambridge), 2024-04, Vol.15 (14), p.5248-5255

2024

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Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15698-15709

2022

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Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

Journal of investigative dermatology, 2017-02, Vol.137 (2), p.430-439

2017

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Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor‑1 Scaffold

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.658-667

2017

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Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Application and Structural Analysis of Triazole‐Bridged Disulfide Mimetics in Cyclic Peptides

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition

Cyclotides: From Structure to Function

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

Characterising the Subsite Specificity of Urokinase‐Type Plasminogen Activator and Tissue‐Type Plasminogen Activator using a Sequence‐Defined Peptide Aldehyde Library

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

Cyclotides as Tools in Chemical Biology

Proteases and proteomics: Cutting to the core of human skin pathologies

Enzymatic C‐to‐C Protein Ligation

Enzymatic C‑Terminal Protein Engineering with Amines

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

Nucleation of a key beta-turn promotes cyclotide oxidative folding

Proteases: common culprits in human skin disorders

Cystine Knot Peptides with Tuneable Activity and Mechanism

An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β‑Factor XIIa in a Cyclotide Scaffold

Binding Loop Substitutions in the Cyclic Peptide SFTI‑1 Generate Potent and Selective Chymase Inhibitors

Tertiary amide bond formation by an engineered asparaginyl ligase

Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor‑1 Scaffold

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