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Derangement of immune responses by myeloid suppressor cells

Cancer Immunology, Immunotherapy, 2004-02, Vol.53 (2), p.64-72

2004

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Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients

Clinical cancer research, 2018-06, Vol.24 (12), p.2859-2872

2018

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B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (24), p.8345-8350

2008

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712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC)

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A807-A807

2023

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Molecular basis and current strategies of therapeutic arginine depletion for cancer

International journal of cancer, 2016-08, Vol.139 (3), p.501-509

2016

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Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Blood, 2020-09, Vol.136 (10), p.1155-1160

2020

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Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

Nature immunology, 2010-11, Vol.11 (11), p.1039-1046

2010

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Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Blood, 2013-08, Vol.122 (5), p.749-758

2013

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Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

Blood, 2015-04, Vol.125 (15), p.2386-2396

2015

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Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia

Journal of clinical oncology, 2019-03, Vol.37 (7), p.580-588

2019

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Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Journal of hematology and oncology, 2018-05, Vol.11 (1), p.68-5, Article 68

2018

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Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells

Blood, 2021-01, Vol.137 (2), p.203-215

2021

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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

The Journal of clinical investigation, 2006-10, Vol.116 (10), p.2777-2790

2006

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Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies

Frontiers in oncology, 2021-05, Vol.11, p.674720-674720

2021

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Nitroaspirin Corrects Immune Dysfunction in Tumor-Bearing Hosts and Promotes Tumor Eradication by Cancer Vaccination

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (11), p.4185-4190

2005

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G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

Clinical & translational immunology, 2022, Vol.11 (5), p.e1395-n/a

2022

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Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Frontiers in oncology, 2018-11, Vol.8, p.553

2018

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

Cancer Immunology, Immunotherapy, 2022-07, Vol.71 (7), p.1583-1596

2022

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Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

International journal of cancer, 2019-10, Vol.145 (8), p.2201-2208

2019

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MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers

EBioMedicine, 2019-09, Vol.47, p.235-246

2019

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The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

International journal of cancer, 2018-04, Vol.142 (7), p.1490-1502

2018

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Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15), p.3043-3053

2015

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Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models

British journal of cancer, 2024-04, Vol.130 (12), p.1990-2002

2024

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Neuroblastoma arginine addiction subverts the anticancer immune response

Oncoimmunology, 2016-02, Vol.5 (2), p.e1078967-e1078967

2016

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Derangement of immune responses by myeloid suppressor cells

Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients

B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo

712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC)

Molecular basis and current strategies of therapeutic arginine depletion for cancer

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target

Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies

Nitroaspirin Corrects Immune Dysfunction in Tumor-Bearing Hosts and Promotes Tumor Eradication by Cancer Vaccination

PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults

G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity

Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models

Neuroblastoma arginine addiction subverts the anticancer immune response

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