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The drugs of sleeping sickness: Their mechanisms of action and resistance, and a brief history

Tropical medicine and infectious disease, 2020-03, Vol.5 (1), p.1-23

P De Koning, Harry

2020

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Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10996-11001

2012

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The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense

Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.622

2023

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Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Trends in parasitology, 2013-03, Vol.29 (3), p.110-118

2013

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Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Nature communications, 2019-12, Vol.10 (1), p.5564-11, Article 5564

2019

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The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference

Frontiers in pharmacology, 2015-09, Vol.6, p.185-185

2015

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Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Medicinal research reviews, 2019-09, Vol.39 (5), p.1553-1602

2019

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Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

The Journal of biological chemistry, 2020-06, Vol.295 (24), p.8331-8347

2020

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Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines

Parasitology research (1987), 2023-12, Vol.122 (12), p.2751-2772

2023

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Design and synthesis of a series of truncated neplanocin fleximers

Molecules (Basel, Switzerland), 2014-12, Vol.19 (12), p.21200-21214

2014

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Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition

PLoS pathogens, 2021-07, Vol.17 (7), p.e1009734-e1009734

2021

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Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

International journal for parasitology -- drugs and drug resistance, 2024-08, Vol.25, p.100533-100533, Article 100533

2024

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Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Frontiers in pharmacology, 2015-03, Vol.6, p.32-32

2015

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Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals

International journal of molecular sciences, 2022-03, Vol.23 (5), p.2844

2022

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Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis

PLoS pathogens, 2015-06, Vol.11 (6), p.e1004942

2015

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Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

Molecules (Basel, Switzerland), 2021-06, Vol.26 (13), p.3912

2021

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Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

PLoS neglected tropical diseases, 2020-07, Vol.14 (7), p.e0008458-e0008458

2020

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Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya

PloS one, 2016-05, Vol.11 (5), p.e0155355

2016

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Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Nucleic acids research, 2017-08, Vol.45 (14), p.8378

2017

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Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

International journal of molecular sciences, 2023-02, Vol.24 (4), p.3144

2023

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The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues

Molecules (Basel, Switzerland), 2022-11, Vol.27 (22), p.8045

2022

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The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

Molecules (Basel, Switzerland), 2020-11, Vol.25 (21), p.5155

2020

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Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

Molecules (Basel, Switzerland), 2022-11, Vol.27 (22), p.8087

2022

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Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters

International journal of molecular sciences, 2022-08, Vol.23 (15), p.8139

2022

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The drugs of sleeping sickness: Their mechanisms of action and resistance, and a brief history

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense

Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines

Design and synthesis of a series of truncated neplanocin fleximers

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition

Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis

Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues

The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches

Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters

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