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Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction

Drug metabolism and disposition, 2006-04, Vol.34 (4), p.591-599

2006

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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Nature protocols, 2010-09, Vol.5 (9), p.1540-1551

2010

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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

Expert opinion on drug metabolism & toxicology, 2006-12, Vol.2 (6), p.875-894

2006

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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.489-503

2017

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First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.935-942

2015

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An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

Toxicology (Amsterdam), 2005-12, Vol.216 (2), p.154-167

2005

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

PLoS medicine, 2016-10, Vol.13 (10), p.e1002138

2016

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Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.1047-1054

2006

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An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR

Chemico-biological interactions, 2004-12, Vol.151 (1), p.1-11

2004

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Letter to the Editor, Physiologically based pharmacokinetic predictions of intestinal BCRP‐mediated effect of telmisartan on the pharmacokinetics of rosuvastatin in humans

Biopharmaceutics & drug disposition, 2017-10, Vol.38 (7), p.443-444

2017

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Cancer discovery, 2022-06, Vol.12 (6), p.1500-1517

2022

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Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8077-8098

2024

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Macitentan does not interfere with hepatic bile salt transport

The Journal of pharmacology and experimental therapeutics, 2014-07, Vol.350 (1), p.130-143

2014

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Discovery of a Potent, Selective T‑type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9769-9789

2017

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Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10661-10675

2016

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Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

Clinical pharmacokinetics, 2016-03, Vol.55 (3), p.369-380

2016

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The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag

Xenobiotica, 2018-07, Vol.48 (7), p.704-719

2018

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S1P1 Modulator-Induced G αi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

Molecular pharmacology, 2018-02, Vol.93 (2), p.109-118

2018

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S1P 1 Modulator-Induced G α i Signaling and β -Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

Molecular pharmacology, 2018-02, Vol.93 (2), p.109-118

2018

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Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry—Do they comply with FDA recommendations?

Chemico-biological interactions, 2007-05, Vol.168 (1), p.51-65

2007

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Correction to Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.2163-2163

2017

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Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.658-662

2013

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Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

First-in-humans study of the safety, tolerability, and pharmacokinetics of ACT-451840, a new chemical entity with antimalarial activity

Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies

An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine

An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR

Letter to the Editor, Physiologically based pharmacokinetic predictions of intestinal BCRP‐mediated effect of telmisartan on the pharmacokinetics of rosuvastatin in humans

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases

Macitentan does not interfere with hepatic bile salt transport

Discovery of a Potent, Selective T‑type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers

Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag

Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models

S1P1 Modulator-Induced G αi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

S1P 1 Modulator-Induced G α i Signaling and β -Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo

Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry—Do they comply with FDA recommendations?

Correction to Structure–Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T‑Type Calcium Channel Blockers

Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold

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