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CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site
Biochemical pharmacology, 2024-08, p.116464, Article 116464
2024
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GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment
iScience, 2024-05, Vol.27 (5), p.109738-109738, Article 109738
2024
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ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells
Journal of experimental & clinical cancer research, 2024-01, Vol.43 (1), p.4-4, Article 4
2024
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Targeting Integrins for Cancer Therapy - Disappointments and Opportunities
Frontiers in cell and developmental biology, 2022-03, Vol.10, p.863850-863850
2022
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Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors
ChemMedChem, 2021-02, Vol.16 (4), p.640-645
2021
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Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
British journal of cancer, 2021-01, Vol.124 (1), p.49-57
2021
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Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2
Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9146-9161
2018
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A two‐state model for the kinetics of competitive radioligand binding
British journal of pharmacology, 2018-05, Vol.175 (10), p.1719-1730
2018
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Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells
Molecular cancer research, 2017-12, Vol.15 (12), p.1656-1666
2017
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Abstract 4584: Apoptosis-mediated AXL activation: Contribution to metastatic cancers
Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4584-4584
2016
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The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity
Cell systems, 2015-07, Vol.1 (1), p.25-36
2015
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Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Bioorganic & medicinal chemistry, 2015-07, Vol.23 (14), p.4034-4049
2015
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Evaluation of (4-Arylpiperidin-1-yl)cyclopentanecarboxamides As High-Affinity and Long-Residence-Time Antagonists for the CCR2 Receptor
ChemMedChem, 2015-07, Vol.10 (7), p.1249-1258
2015
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When structure–affinity relationships meet structure–kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists
European journal of medicinal chemistry, 2015-03, Vol.93, p.121-134
2015
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonistsElectronic supplementary information (ESI) available: Purity data, general chemistry aspects, synthetic procedures, materials and experimental details for the assays, 1H, 13C and gHSQC NMR spectra, HPLC analysis, and MS spectra of all compounds. See DOI: 10.1039/c4ob02397h
2015-02
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Organic & biomolecular chemistry, 2015-01, Vol.13 (8), p.2407-2422
2015
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Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2
Molecular pharmacology, 2014-10, Vol.86 (4), p.358-368
2014
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Bias in chemokine receptor signalling
Trends in immunology, 2014-06, Vol.35 (6), p.243-252
2014
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Structure–Kinetic RelationshipsAn Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists
Journal of medicinal chemistry, 2013-10, Vol.56 (19), p.7706-7714
2013
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Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2
Molecular pharmacology, 2013-10, Vol.84 (4), p.551-561
2013
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Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers
Biochemical pharmacology, 2011-09, Vol.82 (6), p.658
2011
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Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers
Biochemical pharmacology, 2011-09, Vol.82 (6), p.658-668
2011
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Functionally biased modulation of A sub(3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers)
Biochemical pharmacology, 2011-09, Vol.82 (6), p.658-668
2011
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Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies
Clinical cancer research, 2011-07, Vol.17 (13), p.4451-4461
2011
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A Series of 2,4-Disubstituted Quinolines as a New Class of Allosteric Enhancers of the Adenosine A3 Receptor
Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.926-931
2009
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