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Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8775

2021

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Yeast as a Model to Find New Drugs and Drug Targets for VPS13 -Dependent Neurodegenerative Diseases

International journal of molecular sciences, 2022-05, Vol.23 (9), p.5106

2022

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Suppression of Vps13 adaptor protein mutants reveals a central role for PI4P in regulating prospore membrane extension

PLoS genetics, 2021-08, Vol.17 (8), p.e1009727-e1009727

2021

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The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus

International journal of molecular sciences, 2021-11, Vol.22 (22), p.12274

2021

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Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1193

2021

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Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate

Human molecular genetics, 2017-04, Vol.26 (8), p.1497-1510

2017

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Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

Traffic (Copenhagen, Denmark), 2017-11, Vol.18 (11), p.711-719

2017

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Targeting Copper Homeostasis Improves Functioning of vps13 Δ Yeast Mutant Cells, a Model of VPS13 -Related Diseases

International journal of molecular sciences, 2021-02, Vol.22 (5), p.2248

2021

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Molecular Basis of the Pathogenic Mechanism Induced by the m.9191T>C Mutation in Mitochondrial ATP6 Gene

International journal of molecular sciences, 2020-07, Vol.21 (14), p.5083

2020

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Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

Disease models & mechanisms, 2019-01, Vol.12 (1)

2019

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Flavonoids as Potential Drugs for VPS13 -Dependent Rare Neurodegenerative Diseases

Genes, 2020-07, Vol.11 (7), p.828

2020

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Mimicking the phosphorylation of Rsp5 in PKA site T761 affects its function and cellular localization

European journal of cell biology, 2015-12, Vol.94 (12), p.576-588

2015

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Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro

European journal of cell biology, 2011-12, Vol.90 (12), p.1016-1028

2011

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Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase

Biochemical journal, 2006-04, Vol.395 (1), p.173-181

2006

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Rsp5p Is Required for ER Bound Mga2p120 Polyubiquitination and Release of the Processed/Tethered Transactivator Mga2p90

Current biology, 2003-07, Vol.13 (14), p.1227-1233

2003

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Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae

RNA (Cambridge), 2005-11, Vol.11 (11), p.1710-1718

2005

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WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the LPKY motif of Spt23p and Mga2p

The international journal of biochemistry & cell biology, 2008-01, Vol.40 (1), p.147-157

2008

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Characterization of nuclear localization and nuclear export signals of yeast actin-binding protein Pan1

FEBS letters, 2007-11, Vol.581 (28), p.5371-5376

2007

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Pan1p, an actin cytoskeleton-associated protein, is required for growth of yeast on oleate medium

Experimental cell research, 2005-11, Vol.310 (2), p.482-492

2005

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The role of Rsp5 ubiquitin ligase in regulation of diverse processes in yeast cells

Acta biochimica polonica, 2008-01, Vol.55 (4), p.649-662

2008

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Phosphatidylinositol-3-phosphate regulates response of cells to proteotoxic stress

The international journal of biochemistry & cell biology, 2016-10, Vol.79, p.494-504

2016

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Rsp5p, a New Link between the Actin Cytoskeleton and Endocytosis in the Yeast Saccharomyces cerevisiae

Molecular and Cellular Biology, 2002-10, Vol.22 (20), p.6946-6948

2002

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MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5

Genetics (Austin), 1997-03, Vol.145 (3), p.595-603

1997

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Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain

Acta biochimica Polonica, 2011-01, Vol.58 (3), p.365

2011

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Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial delivery

Molecular and Cellular Biology, 1995-12, Vol.15 (12), p.6884-6894

1995

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Yeast Models and Molecular Mechanisms of Neurodegenerative Diseases

Yeast as a Model to Find New Drugs and Drug Targets for VPS13 -Dependent Neurodegenerative Diseases

Suppression of Vps13 adaptor protein mutants reveals a central role for PI4P in regulating prospore membrane extension

The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus

Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate

Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease

Targeting Copper Homeostasis Improves Functioning of vps13 Δ Yeast Mutant Cells, a Model of VPS13 -Related Diseases

Molecular Basis of the Pathogenic Mechanism Induced by the m.9191T>C Mutation in Mitochondrial ATP6 Gene

Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

Flavonoids as Potential Drugs for VPS13 -Dependent Rare Neurodegenerative Diseases

Mimicking the phosphorylation of Rsp5 in PKA site T761 affects its function and cellular localization

Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro

Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase

Rsp5p Is Required for ER Bound Mga2p120 Polyubiquitination and Release of the Processed/Tethered Transactivator Mga2p90

Rsp5 ubiquitin ligase modulates translation accuracy in yeast Saccharomyces cerevisiae

WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the LPKY motif of Spt23p and Mga2p

Characterization of nuclear localization and nuclear export signals of yeast actin-binding protein Pan1

Pan1p, an actin cytoskeleton-associated protein, is required for growth of yeast on oleate medium

The role of Rsp5 ubiquitin ligase in regulation of diverse processes in yeast cells

Phosphatidylinositol-3-phosphate regulates response of cells to proteotoxic stress

Rsp5p, a New Link between the Actin Cytoskeleton and Endocytosis in the Yeast Saccharomyces cerevisiae

MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5

Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain

Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial delivery

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