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Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation

Molecules (Basel, Switzerland), 2017-08, Vol.22 (9), p.1440

2017

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Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

Pharmaceuticals (Basel, Switzerland), 2023-07, Vol.16 (7), p.1000

2023

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Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones

Bioorganic & medicinal chemistry, 2011-04, Vol.19 (7), p.2306-2325

2011

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Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

Pharmaceuticals (Basel, Switzerland), 2022-08, Vol.15 (9), p.1044

2022

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Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Pharmaceuticals (Basel, Switzerland), 2021-10, Vol.14 (11), p.1119

2021

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Exploring the Anti-Cancer Mechanism of Novel 3,4'-Substituted Diaryl Guanidinium Derivatives

Pharmaceuticals (Basel, Switzerland), 2020-12, Vol.13 (12), p.485

2020

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Targeting inhibitor of apoptosis proteins (IAPs) with IAP inhibitors sensitises malignant rhabdoid tumour cells to cisplatin

Cancer treatment and research communications, 2022-01, Vol.32, p.100579-100579, Article 100579

2022

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Evaluation of targeting autophagy for the treatment of malignant rhabdoid tumours

Cancer treatment and research communications, 2022-01, Vol.32, p.100584-100584, Article 100584

2022

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Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species

Toxicology and applied pharmacology, 2021-09, Vol.427, p.115646, Article 115646

2021

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Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

Pharmaceuticals (Basel, Switzerland), 2021-02, Vol.14 (2), p.169

2021

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Combretastatins: more than just vascular targeting agents?

The Journal of pharmacology and experimental therapeutics, 2015-11, Vol.355 (2), p.212-227

2015

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Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin

Experimental cell research, 2024-04, Vol.437 (1), p.113995-113995, Article 113995

2024

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3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

Pharmaceuticals (Basel, Switzerland), 2019-04, Vol.12 (2), p.56

2019

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The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours

Journal of cancer research and clinical oncology, 2023-09, Vol.149 (11), p.8379-8391

2023

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BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines

Molecular pharmacology, 2008-02, Vol.73 (2), p.419-430

2008

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The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway

International journal of oncology, 2019-07, Vol.55 (1), p.191-202

2019

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Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents

European journal of medicinal chemistry, 2017-01, Vol.125, p.453-463

2017

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Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

Bioorganic & medicinal chemistry, 2008-11, Vol.16 (21), p.9554-9573

2008

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Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1401-1420

2011

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Synthesis and Biochemical Evaluation of 3‑Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.90-113

2016

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Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.514-534

2018

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Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines

Molecular pharmacology, 2006-07, Vol.70 (1), p.60-70

2006

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β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells

European journal of medicinal chemistry, 2020-03, Vol.189, p.112050-112050, Article 112050

2020

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Target Specific Virtual Screening: Optimization of an Estrogen Receptor Screening Platform

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5301-5310

2007

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Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers

Bioorganic chemistry, 2023-12, Vol.141, p.106877-106877, Article 106877

2023

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Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation

Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones

Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Exploring the Anti-Cancer Mechanism of Novel 3,4'-Substituted Diaryl Guanidinium Derivatives

Targeting inhibitor of apoptosis proteins (IAPs) with IAP inhibitors sensitises malignant rhabdoid tumour cells to cisplatin

Evaluation of targeting autophagy for the treatment of malignant rhabdoid tumours

Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species

Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

Combretastatins: more than just vascular targeting agents?

Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours

BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines

The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway

Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents

Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies

Synthesis and Biochemical Evaluation of 3‑Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines

β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells

Target Specific Virtual Screening: Optimization of an Estrogen Receptor Screening Platform

Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers

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