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On the polarity of partially fluorinated methyl groups

Journal of fluorine chemistry, 2013-08, Vol.152, p.119-128

2013

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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

ChemMedChem, 2007-08, Vol.2 (8), p.1100-1115

2007

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Strain-Accelerated Formation of Chiral, Optically Active Buta-1,3-dienes

Angewandte Chemie (International ed.), 2015-01, Vol.54 (1), p.349-354

International ed. in English, 2015

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Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

Chemistry : a European journal, 2015-01, Vol.21 (1), p.126-135

2015

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Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9041-9060

2015

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Spannungsvermittelte Bildung chiraler, optisch aktiver Buta‐1,3‐diene

Angewandte Chemie, 2015-01, Vol.127 (1), p.356-361

2015

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Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

ChemMedChem, 2016-10, Vol.11 (19), p.2216-2239

2016

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Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent‐Exposed Ribose‐33 Pocket of tRNA‐Guanine Transglycosylase

Chemistry : a European journal, 2018-07, Vol.24 (39), p.9957-9967

2018

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Frontispiece: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

Chemistry : a European journal, 2015-01, Vol.21 (1), p.n/a

2015

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A short and efficient synthesis of the NMDA glycine site antagonist: (3 R,4 R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)

Tetrahedron letters, 2008-10, Vol.49 (42), p.6079-6080

2008

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Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.6960-6965

2010

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Spannungsvermittelte Bildung chiraler, optisch aktiver Buta-1,3-diene

Angewandte Chemie, 2015-01, Vol.127 (1), p.356-361

2015

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Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4311-4315

2006

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4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4321-4325

2006

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A Straightforward and Efficiently Scaleable Synthesis of Novel Racemic 4-Substituted-2,8-diazaspiro[4.5]decan-1-one Derivatives

Synthesis (Stuttgart), 2005-12, Vol.2005 (19), p.3245-3252

2005

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Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4305-4310

2006

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Aminomethylpyridines as DPP-IV inhibitors

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3579-3580

2004

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HEUSGEN, CHRISTOPH: Ludwig Erhards Lehre von der Sozialen Marktwirtschaft (Book Review)

Kyklos, 1984, Vol.37 (3), p.491

Zimmerli, Daniel

1984

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4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a Novel Class of Highly Selective GlyT1 Inhibitors with Superior Pharmacological and Pharmacokinetic Parameters

ChemInform, 2006-12, Vol.37 (51), p.no-no

2006

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Discovery of 4-Substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro [4.5]decan-1-one as a Novel Class of Highly Selective GlyT1 Inhibitors with Improved Metabolic Stability

ChemInform, 2006-12, Vol.37 (51), p.no-no

2006

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Aminomethylpyridines as DPP-IV Inhibitors

ChemInform, 2004-10, Vol.35 (41), p.no-no

2004

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

Cancer cell, 2018-07, Vol.34 (1), p.69-84.e14

2018

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Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America

Clinical infectious diseases, 2013-01, Vol.56 (1), p.1-10

2013

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On the polarity of partially fluorinated methyl groups

Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Strain-Accelerated Formation of Chiral, Optically Active Buta-1,3-dienes

Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Spannungsvermittelte Bildung chiraler, optisch aktiver Buta‐1,3‐diene

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent‐Exposed Ribose‐33 Pocket of tRNA‐Guanine Transglycosylase

Frontispiece: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT)

A short and efficient synthesis of the NMDA glycine site antagonist: (3 R,4 R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)

Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors

Spannungsvermittelte Bildung chiraler, optisch aktiver Buta-1,3-diene

Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

A Straightforward and Efficiently Scaleable Synthesis of Novel Racemic 4-Substituted-2,8-diazaspiro[4.5]decan-1-one Derivatives

Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors

Aminomethylpyridines as DPP-IV inhibitors

HEUSGEN, CHRISTOPH: Ludwig Erhards Lehre von der Sozialen Marktwirtschaft (Book Review)

4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a Novel Class of Highly Selective GlyT1 Inhibitors with Superior Pharmacological and Pharmacokinetic Parameters

Discovery of 4-Substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro [4.5]decan-1-one as a Novel Class of Highly Selective GlyT1 Inhibitors with Improved Metabolic Stability

Aminomethylpyridines as DPP-IV Inhibitors

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America

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