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Soluble Guanylate Cyclase Stimulators and Activators

Handbook of experimental pharmacology, 2021, Vol.264, p.355-394

2021

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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

Frontiers in pharmacology, 2020-04, Vol.11, p.419-419

2020

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An impaired natriuretic peptide hormone system may play a role in COVID‐19 severity in vulnerable populations

FASEB bioAdvances, 2020-10, Vol.2 (10), p.596-599

2020

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Nitrogen Regulatory Protein C-Controlled Genes of Escherichia coli: Scavenging as a Defense against Nitrogen Limitation

Proceedings of the National Academy of Sciences - PNAS, 2000-12, Vol.97 (26), p.14674-14679

2000

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Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains

Nature biotechnology, 2003-02, Vol.21 (2), p.150-156

2003

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Structural Origins of Adenine-Tract Bending

Proceedings of the National Academy of Sciences - PNAS, 2003-03, Vol.100 (5), p.2369-2373

2003

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

Pharmacology research & perspectives, 2020-04, Vol.8 (2), p.e00579-n/a

2020

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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

The Journal of pharmacology and experimental therapeutics, 2018-06, Vol.365 (3), p.664-675

2018

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Correction to: Soluble Guanylate Cyclase Stimulators and Activators

Reactive Oxygen Species, p.425-425

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An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

Diabetologia, 2020-04, Vol.63 (4), p.733-743

2020

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Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells

American journal of physiology. Renal physiology, 2020-10, Vol.319 (4), p.F697-F711

2020

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The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S699-S699

2017

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The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers

Hypertension (Dallas, Tex. 1979), 2009-05, Vol.53 (5), p.867-876

2009

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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator

Bioorganic & medicinal chemistry letters, 2021-05, Vol.40, p.127886, Article 127886

2021

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Isolation of Escherichia coli mRNA and Comparison of Expression Using mRNA and Total RNA on DNA Microarrays

Analytical biochemistry, 2001-03, Vol.290 (2), p.205-213

2001

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Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

ACS medicinal chemistry letters, 2016-05, Vol.7 (5), p.465-469

2016

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Genome Image Programs: Visualization and Interpretation of Escherichia coli Microarray Experiments

Genetics (Austin), 2004-08, Vol.167 (4), p.2111-2119

2004

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Mo1504 - The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S699-S699

2017

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Rapid Dose Escalation Study of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in Patients with Diabetes and Hypertension

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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The soluble guanylate cyclase stimulator IWP‐550 inhibits neuroinflammation in vitro and in vivo

The FASEB journal, 2018-04, Vol.32 (S1), p.823.3-823.3

2018

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THE NATRIURETIC PEPTIDE UROGUANYLIN ELICITS PHYSIOLOGIC ACTIONS THROUGH TWO DISTINCT TOPOISOMERS

Hypertension (Dallas, Tex. 1979), 2009-03, Vol.53 (5), p.867-876

2009

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Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution

Circulation (New York, N.Y.), 2016-11, Vol.134 (Suppl_1 Suppl 1), p.A16938-A16938

2016

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Escherichia coli spotted double-strand DNA microarrays: RNA extraction, labeling, hybridization, quality control, and data management

Methods in molecular biology (Clifton, N.J.), 2003, Vol.224, p.61

2003

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NMR of Enzymatically Synthesized Uniformly13C15N-Labeled DNA Oligonucleotides

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (8), p.3091-3095

1995

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NMR of enzymatically synthesized uniformly 13C15N-labled DNA oligonucleotides

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (8), p.3091

1995

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Soluble Guanylate Cyclase Stimulators and Activators

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

An impaired natriuretic peptide hormone system may play a role in COVID‐19 severity in vulnerable populations

Nitrogen Regulatory Protein C-Controlled Genes of Escherichia coli: Scavenging as a Defense against Nitrogen Limitation

Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains

Structural Origins of Adenine-Tract Bending

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

Correction to: Soluble Guanylate Cyclase Stimulators and Activators

An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells

The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo

The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers

Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator

Isolation of Escherichia coli mRNA and Comparison of Expression Using mRNA and Total RNA on DNA Microarrays

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

Genome Image Programs: Visualization and Interpretation of Escherichia coli Microarray Experiments

Mo1504 - The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo

Rapid Dose Escalation Study of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in Patients with Diabetes and Hypertension

The soluble guanylate cyclase stimulator IWP‐550 inhibits neuroinflammation in vitro and in vivo

THE NATRIURETIC PEPTIDE UROGUANYLIN ELICITS PHYSIOLOGIC ACTIONS THROUGH TWO DISTINCT TOPOISOMERS

Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution

Escherichia coli spotted double-strand DNA microarrays: RNA extraction, labeling, hybridization, quality control, and data management

NMR of Enzymatically Synthesized Uniformly13C15N-Labeled DNA Oligonucleotides

NMR of enzymatically synthesized uniformly 13C15N-labled DNA oligonucleotides

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