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Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment

JCI insight, 2017-11, Vol.2 (21)

2017

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Intramolecular Formal Aza-[3 + 3] Cycloaddition Approach to Indoloquinolizidine Alkaloids. A Stereoselective Total Synthesis of (±)-Tangutorine

Organic letters, 2003-11, Vol.5 (24), p.4709-4712

2003

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Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors

Journal of medicinal chemistry, 2012-01, Vol.55 (1), p.115-125

2012

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The First Stereoselective Ficini−Claisen Rearrangement Using Chiral Ynamides

Organic letters, 2002-04, Vol.4 (8), p.1383-1386

2002

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A Stereoselective Intramolecular Halo-Etherification of Chiral Enamides in the Synthesis of Halogenated Cyclic Ethers

Organic letters, 2007-10, Vol.9 (22), p.4459-4462

2007

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Current methods for the synthesis of 2-substituted azoles

Tetrahedron, 2004-10, Vol.60 (41), p.8991-9016

2004

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Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and Spread

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1140-1158

2015

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Highly Stereoselective Synthesis of Novel α-Haloenamides via a Mild and Efficient Hydrohalogenation of Ynamides

Organic letters, 2003-05, Vol.5 (9), p.1547-1550

2003

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Synthesis and structure–activity relationships of 1,2,3,4-tetrahydropyrido[2,3- b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (12), p.4351-4362

2010

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Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3877-3880

2011

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Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.164-167

2011

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Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1850-1853

2012

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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.133-137

2012

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Cycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1-b]thiazoles

Organic letters, 2007-10, Vol.9 (21), p.4099-4102

2007

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Total syntheses of enantiomerically enriched R-(+)- and S-(-)-deplancheine

Organic & biomolecular chemistry, 2005-06, Vol.3 (11), p.2140-2144

2005

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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.660-663

2011

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A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

Journal of organic chemistry, 2003-03, Vol.68 (5), p.1729-1735

2003

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Lewis Acid Promoted Hetero [2 + 2] Cycloaddition Reactions of Aldehydes with 10-Propynyl-9(10H)-acridone. A Highly Stereoselective Synthesis of Acrylic Acid Derivatives and 1,3-Dienes Using an Electron Deficient Variant of Ynamine

Organic letters, 1999-10, Vol.1 (8), p.1237-1240

1999

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A Rare Acid-Promoted Elimination of O-Methyl Oximes: A Practical Synthesis of 3-Cyano-4-benzopyrones

Journal of organic chemistry, 1999-11, Vol.64 (23), p.8736-8740

1999

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Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β-Unsaturated Iminium Ions with 1,3-Dicarbonyl Equivalents

Organic letters, 2001-07, Vol.3 (14), p.2141-2144

2001

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Recent advances in the chemistry of ynamines and ynamides

Tetrahedron, 2001-09, Vol.57 (36), p.7575-7606

2001

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Synthesis of α-Carboline

Organic syntheses, 2016, Vol.93, p.272-285

He, Linli

2016

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Efficient preparations of novel ynamides and allenamides

Tetrahedron, 2001-01, Vol.57 (3), p.459-466

2001

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Synthesis of 2-(α-substituted-amidoalkyl)-imidazoles

Tetrahedron letters, 2005-07, Vol.46 (28), p.4789-4792

2005

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Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: Unique structural analogs of tacrine based on the BCD-ring of arisugacin

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.973-978

1999

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Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment

Intramolecular Formal Aza-[3 + 3] Cycloaddition Approach to Indoloquinolizidine Alkaloids. A Stereoselective Total Synthesis of (±)-Tangutorine

Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors

The First Stereoselective Ficini−Claisen Rearrangement Using Chiral Ynamides

A Stereoselective Intramolecular Halo-Etherification of Chiral Enamides in the Synthesis of Halogenated Cyclic Ethers

Current methods for the synthesis of 2-substituted azoles

Design, Synthesis, and Biological Evaluation of Sulfonyl Acrylonitriles as Novel Inhibitors of Cancer Metastasis and Spread

Highly Stereoselective Synthesis of Novel α-Haloenamides via a Mild and Efficient Hydrohalogenation of Ynamides

Synthesis and structure–activity relationships of 1,2,3,4-tetrahydropyrido[2,3- b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase

Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors

Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Cycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1-b]thiazoles

Total syntheses of enantiomerically enriched R-(+)- and S-(-)-deplancheine

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

Lewis Acid Promoted Hetero [2 + 2] Cycloaddition Reactions of Aldehydes with 10-Propynyl-9(10H)-acridone. A Highly Stereoselective Synthesis of Acrylic Acid Derivatives and 1,3-Dienes Using an Electron Deficient Variant of Ynamine

A Rare Acid-Promoted Elimination of O-Methyl Oximes: A Practical Synthesis of 3-Cyano-4-benzopyrones

Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β-Unsaturated Iminium Ions with 1,3-Dicarbonyl Equivalents

Recent advances in the chemistry of ynamines and ynamides

Synthesis of α-Carboline

Efficient preparations of novel ynamides and allenamides

Synthesis of 2-(α-substituted-amidoalkyl)-imidazoles

Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: Unique structural analogs of tacrine based on the BCD-ring of arisugacin

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