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Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

Scientific reports, 2021-06, Vol.11 (1), p.13317-13317, Article 13317

2021

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A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

PLoS pathogens, 2017-12, Vol.13 (12), p.e1006679-e1006679

2017

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Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7158-7175

2024

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The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

PLoS neglected tropical diseases, 2024-02, Vol.18 (2), p.e0012007-e0012007

2024

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An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases

Nature communications, 2022-10, Vol.13 (1), p.5989-5989, Article 5989

2022

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ATPaseTb2, a unique membrane-bound FoF1-ATPase component, is essential in bloodstream and dyskinetoplastic trypanosomes

PLoS pathogens, 2015-02, Vol.11 (2), p.e1004660-e1004660

2015

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Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

PLoS biology, 2020-06, Vol.18 (6), p.e3000741-e3000741

2020

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Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

The Journal of biological chemistry, 2020-06, Vol.295 (24), p.8331-8347

2020

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Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6‑Oxopurine Phosphoribosyltransferases

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4030-4057

2022

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Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation

PLoS pathogens, 2023-10, Vol.19 (10), p.e1011699-e1011699

2023

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Mitochondrial adaptations throughout the Trypanosoma brucei life cycle

The Journal of eukaryotic microbiology, 2022-11, Vol.69 (6), p.e12911-n/a

Zíková, Alena

2022

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Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite

PLoS neglected tropical diseases, 2017-04, Vol.11 (4), p.e0005552-e0005552

2017

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Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline

PLoS pathogens, 2021-03, Vol.17 (3), p.e1009204

2021

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Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes

mBio, 2019-07, Vol.10 (4)

2019

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Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes

Trends in parasitology, 2020-04, Vol.36 (4), p.337-355

2020

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Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway

Nucleic acids research, 2023-07, Vol.51 (12), p.6443-6460

2023

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comprehensive analysis of Trypanosoma brucei mitochondrial proteome

Proteomics (Weinheim), 2009-01, Vol.9 (2), p.434-450

2009

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Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

PLoS neglected tropical diseases, 2018-02, Vol.12 (2), p.e0006301

2018

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Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

Chemistry : a European journal, 2022-11, Vol.28 (62), p.e202201636-n/a

2022

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The F0F1-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei

PLoS pathogens, 2009-05, Vol.5 (5), p.e1000436

2009

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Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet

PLoS pathogens, 2016-04, Vol.12 (4), p.e1005492-e1005492

2016

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Aerobic mitochondria of parasitic protists: Diverse genomes and complex functions

Molecular and biochemical parasitology, 2016-09, Vol.209 (1-2), p.46-57

2016

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Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae”

mSphere, 2022-05, Vol.7 (3), p.e0018922-e0018922

2022

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Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

Antimicrobial agents and chemotherapy, 2022-08, Vol.66 (8), p.e0072722

2022

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Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates

Current genetics, 2005-11, Vol.48 (5), p.277-299

2005

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Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases

ATPaseTb2, a unique membrane-bound FoF1-ATPase component, is essential in bloodstream and dyskinetoplastic trypanosomes

Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6‑Oxopurine Phosphoribosyltransferases

Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation

Mitochondrial adaptations throughout the Trypanosoma brucei life cycle

Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite

Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline

Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes

Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes

Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway

comprehensive analysis of Trypanosoma brucei mitochondrial proteome

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

The F0F1-ATP Synthase Complex Contains Novel Subunits and Is Essential for Procyclic Trypanosoma brucei

Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet

Aerobic mitochondria of parasitic protists: Diverse genomes and complex functions

Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae”

Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens

Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates

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