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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Cell, 2020-10, Vol.183 (2), p.490-502.e18

2020

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (18), p.6584-6589

2008

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Decoding the genomic landscape of chromatin-associated biomolecular condensates

Nature communications, 2024-08, Vol.15 (1), p.6952-16, Article 6952

2024

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Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Molecular cell, 2014-01, Vol.53 (2), p.247-261

2014

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Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity

Cell research, 2021-09, Vol.31 (9), p.1028-1031

2021

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Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

Nature communications, 2015-10, Vol.6 (1), p.8651-8651, Article 8651

2015

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Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation

Chemistry : a European journal, 2015-06, Vol.21 (24), p.8745-8749

2015

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Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases

Journal of hematology and oncology, 2020-09, Vol.13 (1), p.119-119, Article 119

2020

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Targeting androgen receptor phase separation to overcome antiandrogen resistance

Nature chemical biology, 2022-12, Vol.18 (12), p.1341-1350

2022

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Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10205-10219

2017

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Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis

Journal of Chromatography A, 2021-01, Vol.1636, p.461790, Article 461790

2021

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Phase separation ability and phosphatase activity of the SHP1-R360E mutant

Biochemical and biophysical research communications, 2022-04, Vol.600, p.150-155

2022

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Researches on the Space-Time View of the Special Relativity

OAlib (Online), 2017, Vol.4 (1), p.1-8

Zhu, Jidong

2017

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Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation

Chemistry : a European journal, 2015-06, Vol.21 (24), p.8745

2015

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Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (40), p.E9317-E9324

2018

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Phase separation underlies signaling activation of oncogenic NTRK fusions

Proceedings of the National Academy of Sciences - PNAS, 2023-10, Vol.120 (42), p.e2219589120

2023

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A New Understanding of Equivalence of the Accelerating Field and the Gravitational Field

OAlib (Online), 2016, Vol.3 (9), p.1-10

Zhu, Jidong

2016

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Effective approach to ureas through organocatalyzed one-pot process

Tetrahedron letters, 2018-04, Vol.59 (17), p.1614-1618

2018

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Abstract 1475: Discovery of ETS-001, a highly potent allosteric SHP2 inhibitor to treat RTK/RAS-driven cancers

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1475-1475

2021

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Abstract 326: Structural dynamics-based hit generation to disrupt YAP/TAZ-TEAD protein-protein interaction

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.326-326

2021

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Rational design of a potent macrocyclic peptide inhibitor targeting the PD-1/PD-L1 protein-protein interaction

RSC advances, 2021-07, Vol.11 (38), p.2327-23279

2021

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Fluorination of 2-substituted benzo[b]furans with Selectfluor

Organic & biomolecular chemistry, 2015-01, Vol.13 (11), p.3190-3193

2015

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Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins

Cell chemical biology, 2018-11, Vol.25 (11), p.1380-1388.e4

2018

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Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach

Journal of medicinal chemistry, 2024-01, Vol.67 (2), p.1079-1092

2024

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Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3107-3121

2019

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Decoding the genomic landscape of chromatin-associated biomolecular condensates

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation

Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases

Targeting androgen receptor phase separation to overcome antiandrogen resistance

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment

Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis

Phase separation ability and phosphatase activity of the SHP1-R360E mutant

Researches on the Space-Time View of the Special Relativity

Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation

Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity

Phase separation underlies signaling activation of oncogenic NTRK fusions

A New Understanding of Equivalence of the Accelerating Field and the Gravitational Field

Effective approach to ureas through organocatalyzed one-pot process

Abstract 1475: Discovery of ETS-001, a highly potent allosteric SHP2 inhibitor to treat RTK/RAS-driven cancers

Abstract 326: Structural dynamics-based hit generation to disrupt YAP/TAZ-TEAD protein-protein interaction

Rational design of a potent macrocyclic peptide inhibitor targeting the PD-1/PD-L1 protein-protein interaction

Fluorination of 2-substituted benzo[b]furans with Selectfluor

Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins

Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach

Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers

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