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P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages

Cell death & disease, 2020-05, Vol.11 (5), Article 394

2020

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GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

Frontiers in immunology, 2022-03, Vol.13, p.870183-870183

2022

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Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Frontiers in pharmacology, 2021-11, Vol.12, p.783641-783641

2021

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Ensemble-Based Algorithm for Synchrophasor Data Anomaly Detection

IEEE transactions on smart grid, 2019-05, Vol.10 (3), p.2979-2988

2019

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IEEE_Xplore

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease

International journal of biological macromolecules, 2023-07, Vol.244, p.125373-125373, Article 125373

2023

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Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis

International journal of biological sciences, 2020-01, Vol.16 (16), p.3163-3173

2020

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Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways

European heart journal, 2024-01, Vol.45 (4), p.268-283

2024

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HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

International immunopharmacology, 2020-06, Vol.83, p.106383-106383, Article 106383

2020

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Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease

Journal of ethnopharmacology, 2024-01, Vol.319 (Pt 3), p.117291-117291, Article 117291

2024

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HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis

International immunopharmacology, 2023-01, Vol.114, p.109507, Article 109507

2023

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Discovery of Selective P2Y 6 R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy

Journal of medicinal chemistry, 2023-05, Vol.66 (9), p.6315-6332

2023

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Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy

Journal of medicinal chemistry, 2023-05, Vol.66 (9), p.6315-6332

2023

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The role of P2Y6R in cardiovascular diseases and recent development of P2Y6R antagonists

Drug discovery today, 2020-03, Vol.25 (3), p.568-573

2020

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Development of novel NLRP3-XOD dual inhibitors for the treatment of gout

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126944-126944, Article 126944

2020

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Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (8), p.1653-1664

2018

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Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats

Biomedicine & pharmacotherapy, 2017-12, Vol.96, p.727-735

2017

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Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential

European journal of medicinal chemistry, 2022-01, Vol.227, p.113933-113933, Article 113933

2022

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Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist

Phytomedicine (Stuttgart), 2023-07, Vol.115, p.154851-154851, Article 154851

2023

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Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists

European journal of medicinal chemistry, 2019-11, Vol.181, p.111564, Article 111564

2019

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4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3

Phytomedicine (Stuttgart), 2018-03, Vol.42, p.9-17

2018

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Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics

Journal of advanced research, 2024-03

2024

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(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1

Biomedicine & pharmacotherapy, 2017-02, Vol.86, p.88-94

2017

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Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

Acta pharmaceutica Sinica. B, 2024-06

2024

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HQL6 serves as a novel P2Y 14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis

International immunopharmacology, 2023-01, Vol.114, p.109507

2023

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Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y 14 R antagonist

Phytomedicine (Stuttgart), 2023-07, Vol.115, p.154851

2023

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P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Ensemble-Based Algorithm for Synchrophasor Data Anomaly Detection

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease

Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis

Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2

Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease

HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis

Discovery of Selective P2Y 6 R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy

Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy

The role of P2Y6R in cardiovascular diseases and recent development of P2Y6R antagonists

Development of novel NLRP3-XOD dual inhibitors for the treatment of gout

Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout

Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential

Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist

Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists

4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3

Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics

(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1

Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

HQL6 serves as a novel P2Y 14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis

Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y 14 R antagonist

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