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Designing in vivo active DNAzymes

Nature chemistry, 2021-04, Vol.13 (4), p.299-301

2021

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Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Nature communications, 2020-02, Vol.11 (1), p.1015-1015, Article 1015

2020

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Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Chemical reviews, 2012-07, Vol.112 (7), p.3808-3832

2012

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Synthesis and biological applications of fluoro-modified nucleic acids

Organic & biomolecular chemistry, 2017, Vol.15 (45), p.9552-9565

2017

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Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5‑Methylene Pyrrolones

Journal of the American Chemical Society, 2017-05, Vol.139 (17), p.6146-6151

2017

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Suppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group

Nature communications, 2023-09, Vol.14 (1), p.5324-5324, Article 5324

2023

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Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Scientific reports, 2020-09, Vol.10 (1), p.15385-14, Article 15385

2020

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Mechanistic Studies on Histone Catalyzed Cleavage of Apyrimidinic/Apurinic Sites in Nucleosome Core Particles

Journal of the American Chemical Society, 2012-10, Vol.134 (40), p.16734-16741

2012

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Histone-Catalyzed Cleavage of Nucleosomal DNA Containing 2-Deoxyribonolactone

Journal of the American Chemical Society, 2012-05, Vol.134 (19), p.8090-8093

2012

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Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification

Journal of the American Chemical Society, 2018-09, Vol.140 (38), p.11893-11897

2018

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Histone Modification via Rapid Cleavage of C4′-Oxidized Abasic Sites in Nucleosome Core Particles

Journal of the American Chemical Society, 2013-04, Vol.135 (14), p.5274-5277

2013

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Modulation of Pyrene Fluorescence in DNA Probes Depends upon the Nature of the Conformationally Restricted Nucleotide

Journal of organic chemistry, 2008-04, Vol.73 (7), p.2829-2842

2008

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Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

ACS chemical biology, 2015-02, Vol.10 (2), p.622-630

2015

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Double Sugar and Phosphate Backbone-Constrained Nucleotides: Synthesis, Structure, Stability, and Their Incorporation into Oligodeoxynucleotides

Journal of organic chemistry, 2009-05, Vol.74 (9), p.3248-3265

2009

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Free-Radical Ring Closure to Conformationally Locked α-l-Carba-LNAs and Synthesis of Their Oligos: Nuclease Stability, Target RNA Specificity, and Elicitation of RNase H

Journal of organic chemistry, 2010-09, Vol.75 (18), p.6122-6140

2010

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Synthesis of 2′,4′-Propylene-Bridged (Carba-ENA) Thymidine and Its Analogues: The Engineering of Electrostatic and Steric Effects at the Bottom of the Minor Groove for Nuclease and Thermodynamic Stabilities and Elicitation of RNase H

Journal of organic chemistry, 2010-11, Vol.75 (21), p.7112-7128

2010

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2-(4-Tolylsulfonyl)ethoxymethyl (TEM)—a new 2′-OH protecting group for solid-supported RNA synthesis

Organic & biomolecular chemistry, 2007, Vol.5 (2), p.333-343

2007

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Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties

Journal of organic chemistry, 2009-01, Vol.74 (1), p.118-134

2009

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Nitrogen Mustard Induces Formation of DNA–Histone Cross-Links in Nucleosome Core Particles

Chemical research in toxicology, 2019-12, Vol.32 (12), p.2517-2525

2019

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Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles

Nucleic acids research, 2021-01, Vol.49 (1), p.257-268

2021

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Participation of Histones in DNA Damage and Repair within Nucleosome Core Particles: Mechanism and Applications

Accounts of chemical research, 2022-04, Vol.55 (7), p.1059-1073

2022

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5‑Formylcytosine Yields DNA–Protein Cross-Links in Nucleosome Core Particles

Journal of the American Chemical Society, 2017-08, Vol.139 (31), p.10617-10620

2017

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Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations

Organic & biomolecular chemistry, 2008-01, Vol.6 (24), p.4627-4633

2008

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C4’‐Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies

Chemistry : a European journal, 2021-10, Vol.27 (59), p.14738-14746

2021

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Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis

Nucleic acids research, 2021-12, Vol.49 (21), p.12306-12319

2021

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Designing in vivo active DNAzymes

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Synthesis and biological applications of fluoro-modified nucleic acids

Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5‑Methylene Pyrrolones

Suppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Mechanistic Studies on Histone Catalyzed Cleavage of Apyrimidinic/Apurinic Sites in Nucleosome Core Particles

Histone-Catalyzed Cleavage of Nucleosomal DNA Containing 2-Deoxyribonolactone

Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification

Histone Modification via Rapid Cleavage of C4′-Oxidized Abasic Sites in Nucleosome Core Particles

Modulation of Pyrene Fluorescence in DNA Probes Depends upon the Nature of the Conformationally Restricted Nucleotide

Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

Double Sugar and Phosphate Backbone-Constrained Nucleotides: Synthesis, Structure, Stability, and Their Incorporation into Oligodeoxynucleotides

Free-Radical Ring Closure to Conformationally Locked α-l-Carba-LNAs and Synthesis of Their Oligos: Nuclease Stability, Target RNA Specificity, and Elicitation of RNase H

Synthesis of 2′,4′-Propylene-Bridged (Carba-ENA) Thymidine and Its Analogues: The Engineering of Electrostatic and Steric Effects at the Bottom of the Minor Groove for Nuclease and Thermodynamic Stabilities and Elicitation of RNase H

2-(4-Tolylsulfonyl)ethoxymethyl (TEM)—a new 2′-OH protecting group for solid-supported RNA synthesis

Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties

Nitrogen Mustard Induces Formation of DNA–Histone Cross-Links in Nucleosome Core Particles

Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles

Participation of Histones in DNA Damage and Repair within Nucleosome Core Particles: Mechanism and Applications

5‑Formylcytosine Yields DNA–Protein Cross-Links in Nucleosome Core Particles

Unusual radical 6-endo cyclization to carbocyclic-ENA and elucidation of its solution conformation by 600 MHz NMR and ab initio calculations

C4’‐Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies

Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis

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